The role of glycolysis in tumorigenesis: from biological aspects to therapeutic opportunities

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorCordani, Marco
dc.contributor.authorMichetti, Federica
dc.contributor.authorZarrabi, Ali
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorRumio, Cristiano
dc.contributor.authorStrippoli, Raffaele
dc.contributor.authorMarcucci, Fabrizio
dc.date.accessioned2025-04-16T11:38:24Z
dc.date.available2025-04-16T11:38:24Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractGlycolytic metabolism generates energy and intermediates for biomass production. Tumor-associated glycolysis is upregulated compared to normal tissues in response to tumor cell-autonomous or non-autonomous stimuli. The consequences of this upregulation are twofold. First, the metabolic effects of glycolysis become predominant over those mediated by oxidative metabolism. Second, overexpressed components of the glycolytic pathway (i.e. enzymes or metabolites) acquire new functions unrelated to their metabolic effects and which are referred to as "moonlighting" functions. These functions include induction of mutations and other tumor-initiating events, effects on cancer stem cells, induction of increased expression and/or activity of oncoproteins, epigenetic and transcriptional modifications, bypassing of senescence and induction of proliferation, promotion of DNA damage repair and prevention of DNA damage, antiapoptotic effects, inhibition of drug influx or increase of drug efflux. Upregulated metabolic functions and acquisition of new, non-metabolic functions lead to biological effects that support tumorigenesis: promotion of tumor initiation, stimulation of tumor cell proliferation and primary tumor growth, induction of epithelial-mesenchymal transition, autophagy and metastasis, immunosuppressive effects, induction of drug resistance and effects on tumor accessory cells. These effects have negative consequences on the prognosis of tumor patients. On these grounds, it does not come to surprise that tumor-associated glycolysis has become a target of interest in antitumor drug discovery. So far, however, clinical results with glycolysis inhibitors have fallen short of expectations. In this review we propose approaches that may allow to bypass some of the difficulties that have been encountered so far with the therapeutic use of glycolysis inhibitors.
dc.description.sponsorshipAssociazione Italiana per la Ricerca sul Cancro Ministero dell’Istruzione, dell’Università e della Ricerca European Union NextGeneration
dc.identifier.citationCordani, M., Michetti, F., Zarrabi, A., Zarepour, A., Rumio, C., Strippoli, R., & Marcucci, F. (2024). The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities. Neoplasia, 58, 101076.
dc.identifier.doi10.1016/j.neo.2024.101076
dc.identifier.endpage18
dc.identifier.issn1476-5586
dc.identifier.scopus2-s2.0-85207360833
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.neo.2024.101076
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6008
dc.identifier.volume58
dc.identifier.wosWOS:001348665600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherElsevier inc.
dc.relation.ispartofNeoplasia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnticancer Therapies
dc.subjectCancer Stem Cells
dc.subjectGlycolysis
dc.subjectMetabolic Reprogramming
dc.subjectTumorigenesis
dc.titleThe role of glycolysis in tumorigenesis: from biological aspects to therapeutic opportunities
dc.typeArticle

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