Vitamin D3 has antifibrotic effects on rats with epidural fibrosis
Küçük Resim Yok
Tarih
29 Ocak 2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marmara University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: One unfavorable outcome of spinal operations is epidural fibrosis. Recurrent back pain and radiculopathy could negatively
impact the patient’s quality of life. In this study, using a rat laminectomy model, we sought to examine any potential antifibrotic
benefits of vitamin D3.
Patients and Methods: Control, local, and systemic vitamin D3 groups (n = 6 rats per group) were randomly assigned. Laminectomy
alone was carried out in the control group. Vitamin D3 application onto the dura was done in the local D3 group. Intraperitoneal
delivery of the systemic vitamin D3 was carried out in the systemic vitamin D3 group. Epidural fibrosis was studied macroscopically
and histopathologically four weeks later.
Results: The macroscopic epidural fibrosis score was lower in the local and systemic vitamin D3 groups compared to the control
group (p<0.001, for both groups). Comparing the local and systemic vitamin D3 groups to the control group, fibrosis thickness was
significantly decreased (p<0.01, for both groups).
Conclusion: Vitamin D3 could be an alternative treatment for preventing spinal epidural fibrosis.
Açıklama
Anahtar Kelimeler
Epidural fibrosis, Laminectomy, Vitamin D3
Kaynak
Marmara Medical Journel
WoS Q Değeri
Scopus Q Değeri
Cilt
38
Sayı
1
Künye
Kuru Bektaşoğlu, P., Hazneci, J., Somay, A., Börekci, A., et al. (2025). Vitamin D3 has antifibrotic effects on rats with epidural fibrosis. Marmara Medical Journal, 38(1), 62-67. https://doi.org/10.5472/marumj.1629001
