Vitamin D3 has antifibrotic effects on rats with epidural fibrosis

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dc.authoridPınar Kuru Bektaşoğlu / 0000-0001-9889-9955
dc.authoridJülide Hazneci / 0000-0003-2763-2748
dc.authoridAdnan Somay / 0000-0002-8613-8566
dc.authoridAli Börekci / 0000-0002-3687-7934
dc.authoridBora Gürer / 0000-0003-1500-6184
dc.authorscopusidBora Gürer / 36448801100
dc.authorwosidBora Gürer / K-1177-2012
dc.contributor.authorBektaşoğlu, Pınar Kuru
dc.contributor.authorHazneci, Jülide
dc.contributor.authorSomay, Adnan
dc.contributor.authorBörekci, Ali
dc.contributor.authorGürer, Bora
dc.date.accessioned2025-04-18T07:39:11Z
dc.date.available2025-04-18T07:39:11Z
dc.date.issued29 Ocak 2025
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractObjective: One unfavorable outcome of spinal operations is epidural fibrosis. Recurrent back pain and radiculopathy could negatively impact the patient’s quality of life. In this study, using a rat laminectomy model, we sought to examine any potential antifibrotic benefits of vitamin D3. Patients and Methods: Control, local, and systemic vitamin D3 groups (n = 6 rats per group) were randomly assigned. Laminectomy alone was carried out in the control group. Vitamin D3 application onto the dura was done in the local D3 group. Intraperitoneal delivery of the systemic vitamin D3 was carried out in the systemic vitamin D3 group. Epidural fibrosis was studied macroscopically and histopathologically four weeks later. Results: The macroscopic epidural fibrosis score was lower in the local and systemic vitamin D3 groups compared to the control group (p<0.001, for both groups). Comparing the local and systemic vitamin D3 groups to the control group, fibrosis thickness was significantly decreased (p<0.01, for both groups). Conclusion: Vitamin D3 could be an alternative treatment for preventing spinal epidural fibrosis.
dc.identifier.citationKuru Bektaşoğlu, P., Hazneci, J., Somay, A., Börekci, A., et al. (2025). Vitamin D3 has antifibrotic effects on rats with epidural fibrosis. Marmara Medical Journal, 38(1), 62-67. https://doi.org/10.5472/marumj.1629001
dc.identifier.doi10.5472/marumj.1629001
dc.identifier.endpage67
dc.identifier.issn1019-1941
dc.identifier.issue1
dc.identifier.startpage62
dc.identifier.urihttps://doi.org/10.5472/marumj.1629001
dc.identifier.urihttps://dergipark.org.tr/en/pub/marumj/issue/90213/1629001
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6470
dc.identifier.volume38
dc.institutionauthorGürer, Bora
dc.institutionauthoridBora Gürer / 0000-0003-1500-6184
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofMarmara Medical Journel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpidural fibrosis
dc.subjectLaminectomy
dc.subjectVitamin D3
dc.titleVitamin D3 has antifibrotic effects on rats with epidural fibrosis
dc.typeArticle

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