The effects of chard extract against streptozotocin-induced erectile dysfunction in rats

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dc.authoridMustafa Aydın / 0000-0002-4183-6045
dc.authoridOzlem Saçan / 0000-0001-6503-4613
dc.authoridLevent Kabasakal / 0000-0002-5474-6436
dc.authoridSule Cetinel / 0000-0003-1912-3679
dc.authoridMustafa Kadihasanoglu / 0000-0001-5109-5319
dc.authoridMuammer Kendirci / 0000-0002-1854-1871
dc.authoridYeşim İpçi Söbmez / 0009-0003-6476-8799
dc.authoridRefıye Yanardag / 0000-0003-4185-4363
dc.authoridGöksel Şener / 0000-0001-7444-6193
dc.authorscopusidMuammer Kendirci / 8625690500
dc.authorwosidMuammer Kendirci / FBB-6235-2022
dc.contributor.authorAydin, Mustafa
dc.contributor.authorSaçan, Ozlem
dc.contributor.authorKabasakal, Levent
dc.contributor.authorCetinel, Sule
dc.contributor.authorKadihasanoglu, Mustafa
dc.contributor.authorKendirci, Muammer
dc.contributor.authorSöbmez, Yeşim İpçi
dc.contributor.authorYanardag, Refıye
dc.contributor.authorŞener, Göksel
dc.date.accessioned2025-04-18T09:03:30Z
dc.date.available2025-04-18T09:03:30Z
dc.date.issued17.11.2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBackground and Aims: To analyze the potential therapeutic effects of chard against streptozotocin (STZ) -induced erectile dysfunction (ED) and oxidative damage in the corpus cavernousum in rats. Materials and Methods: In this study, Sprague-Dawley rats (250-300g) were allocated into groups as follows: control, diabetic, diabetic + chard, and diabetic + insulin. In order to induce diabetes, rats were given 65 mg/kg intraperitoneal streptozotocin. Chard extract was given orally at a dose 2 g/kg for 45 days beginning on 15th days. Sixty days after STZ injection, intracavernosal pressure (ICP) was measured and rats were decapitated. Blood samples were obtained for glucose, asymmetric dimethylarginine (ADMA)levels, and lactate dehydrogenase (LDH) activity while cavernous tissues were taken to analyze luminol and lucigenin chemiluminescence (CL), malondialdehyde and glutathione and along with histological analysis. Results: The results revealed that diabetes caused significant decreases in cavernosal tissue glutathione levels, while luminol and lucigenin CL, and malondialdehyde levels were significantly elevated. Plasma glucose, ADMA levels, and LDH activity were also found to be increased in diabetic group. On the other hand, both chard extract and insulin treatment reversed these biochemical parameters significantly. Furthermore, it was found that the ICP value examined for evaluating erectile functions were lower in the diabetic group, but increased in both treatment groups which were similar to the control values. Conclusion: According to our results, chard extract, similar to insulin, reduced diabetes-induced oxidative damage in cavernosal tissue and protected erectile functions. This effects may be attributed its hypoglycemic and antioxidant properties.
dc.identifier.citationAYDIN, M., SAÇAN, O., KABASAKAL, L., CETİNEL, S., KADIHASANOGLU, M., KENDIRCI, M., SÖBMEZ, Y. İ., YANARDAG, R., ŞENER, G. (2024). The effects of chard extract against streptozotocin-induced erectile dysfunction in rats. Istanbul Journal of Pharmacy , 54(1), 12 - 19. doi.org/10.26650/IstanbulJPharm.2024.1070319
dc.identifier.doi10.26650/IstanbulJPharm.2024.1070319
dc.identifier.endpage19
dc.identifier.issn2548-0731
dc.identifier.issue1
dc.identifier.startpage12
dc.identifier.trdizinid1279959
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1279959/the-effects-of-chard-extract-against-streptozotocin-induced-erectile-dysfunction-in-rats
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6677
dc.identifier.volume54
dc.identifier.wosWOS:001216536800001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKendirci, Muammer
dc.institutionauthoridMuammer Kendirci / 0000-0002-1854-1871
dc.language.isoen
dc.publisherİstanbul Üniversitesi Yayınevi
dc.relation.ispartofIstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChard extract
dc.subjectdiabetes mellitus
dc.subjecterectile dysfunction
dc.subjectoxidative damage
dc.titleThe effects of chard extract against streptozotocin-induced erectile dysfunction in rats
dc.typeArticle

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