The apoptotic effect of ozone therapy on mitochondria of highly metastatic breast cancer cell line MDA-MB-231 using in vitro approaches

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dc.authoridPolen Koçak / 0000-0003-4493-1061en_US
dc.authorscopusidPolen Koçak / 57191971267en_US
dc.authorwosidPolen Koçak / AGG-7399-2022en_US
dc.authorwosidPolen Koçak / JHP-3402-2023
dc.contributor.authorInac, Elif
dc.contributor.authorUnsal, Naz
dc.contributor.authorYilmaz, Hazal
dc.contributor.authorErkisi, Selena
dc.contributor.authorYildirim, Merve
dc.contributor.authorTanriver, Yildiray
dc.contributor.authorKoçak, Polen
dc.date.accessioned2022-07-05T14:27:11Z
dc.date.available2022-07-05T14:27:11Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractOzone (O3) gas is the triatomic state of oxygen and it is used as a disinfection agent due to its strong oxidizing effect, since its discovery in the mid-nineteenth century. Ozone therapy is also an alternative therapeutic approach for some diseases like circulatory disorders, AIDS, asthma, cardiovascular diseases, and certain types of cancer by increasing the oxygen levels in the blood by external addition of ozone to the body. In this study, the therapeutic potential of ozone therapy was examined by inhibiting the growth of breast cancer cells in a dose-dependent procedure. Ozone concentrations varying from 5 to 20 ?g/ml were applied to the MDA-MB-231, human breast adenocarcinoma and HUVEC, human umbilical vein endothelium, cell lines, and MDA cells demonstrated an increased rate of death while its migration potential decreases. RT-PCR analysis showed mRNA expression levels of pro-apoptotic genes demonstrated higher folds in MDA cells after 10 ?g/ml treatment. In the same context, Annexin V/PI and cell cycle analysis also concluded that ozone therapy causes apoptotic cell death on breast tumor cells. The use of ozone therapy for cancer treatment requires further and extensive research. However, this research has shown that ozone therapy is a promising source for cancer treatment in a way by inhibiting the proliferation of breast tumor cellsen_US
dc.identifier.citationYıldırım, M., Erkişi, S., Yılmaz, H., Ünsal, N., İnaç, E., Tanrıver, Y., & Koçak, P. (2022). The apoptotic effect of ozone therapy on mitochondria of highly metastatic breast cancer cell line MDA-MB-231 using in vitro approaches. Journal of Interventional Medicine, doi:10.1016/j.jimed.2022.03.004en_US
dc.identifier.doi10.1016/j.jimed.2022.03.004en_US
dc.identifier.issn2096-3602en_US
dc.identifier.scopus2-s2.0-85127576366en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttp://doi.org/10.1016/j.jimed.2022.03.004
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2979
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoçak, Polen
dc.language.isoenen_US
dc.publisherKeAien_US
dc.relation.ispartofJournal of Interventional Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOzone Therapen_US
dc.subjectAntioxidantsen_US
dc.subjectApoptosisen_US
dc.subjectBreast Canceren_US
dc.titleThe apoptotic effect of ozone therapy on mitochondria of highly metastatic breast cancer cell line MDA-MB-231 using in vitro approachesen_US
dc.typeArticleen_US

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