An analytical approach to determining pethidine: An investigation of 18 patients’ urine

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dc.contributor.authorArslan, Z.
dc.contributor.authorKartufan, F.F.
dc.contributor.authorKuloglu, Genc, M.
dc.contributor.authorBattal, D.
dc.contributor.authorYayla, M.
dc.contributor.authorTurkmen, Z.
dc.date.accessioned2024-05-19T14:33:53Z
dc.date.available2024-05-19T14:33:53Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPethidine (PET) is an opioid pain-relief medicine with high addiction potential, especially among health professionals. Pethidine is commonly prescribed in Turkey as a pain-relieving medication for operative purposes. Due to its accessibility, low cost, user-friendliness, and effectiveness, PET is often misused by both healthcare professionals and patients. For this reason, analytical determination methods for PET abuse are essential in terms of forensic toxicology. In this study, a fast, reliable, and accurate gas chromatography-mass spectrometry method was developed for the first time in Turkey for the simultaneous detection of PET and its main urinary metabolite norpethidine (NPET). The method was validated in terms of selectivity, linearity, the limit of detection (LOD), the limit of quantification (LOQ), trueness, and precision according to the Scientific Working Group for Forensic Toxicology guidelines. The linear range was between 0.125-25.00 ?g/mL for PET and 1.00–20.00 ?g/mL for NPET. The LOD values for PET and NPET were 0.05 µg/mL and 0.49 µg/mL, while the LOQ values were 0.125 µg/mL and 1.00 µg/mL, respectively. Extraction efficiencies were calculated as 113% for PET and 104% for NPET. The intra-assay and inter-assay precision results were within acceptable limits. In the presented study, the validated method was applied to the urine of 18 patients collected at the 1st and 3rd hours after receiving PET. All samples in the study were collected under patients’ consent and in line with ethical guidelines. © 2023 Elsevier B.V.en_US
dc.description.sponsorshipIstanbul Üniversitesi; Bilimsel Araştırma Projeleri Birimi, İstanbul Teknik Üniversitesi, BAP: 24503en_US
dc.description.sponsorshipThis research was supported by the Research Fund of Istanbul University- Cerrahpaşa Scientific Research Projects Unit (BAP) [Project No: 24503 ].en_US
dc.identifier.doi10.1016/j.jpba.2023.115670
dc.identifier.issn0731-7085
dc.identifier.pmid37647794en_US
dc.identifier.scopus2-s2.0-85168997961en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2023.115670
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4360
dc.identifier.volume235en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDrug Abuseen_US
dc.subjectForensic Toxicologyen_US
dc.subjectGas Chromatography-Mass Spectrometryen_US
dc.subjectOpioiden_US
dc.subjectSolid-Phase Extractionen_US
dc.subjectSubstance Misuseen_US
dc.titleAn analytical approach to determining pethidine: An investigation of 18 patients’ urineen_US
dc.typeArticleen_US

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