In vitro and in vivo evaluation of multi-target-directed Rivastigmine/Memantine/Gingko biloba-loaded nanofibers against Alzheimer's disease

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dc.authoridAydemir, Oğuzhan/0009-0009-5722-3049
dc.authoridVEYSANOGLU, Servan/0000-0003-4555-1749
dc.authoridDURUKSU, Gokhan/0000-0002-3830-2384
dc.authoridERTAS, BUSRA/0000-0001-8374-1098
dc.authorwosidAydemir, Oğuzhan/JUF-1451-2023
dc.authorwosidGüler, Ece/KEJ-1432-2024
dc.authorwosidDURUKSU, Gokhan/F-7304-2018
dc.contributor.authorVeysanoglu, Servan
dc.contributor.authorErtas, Busra
dc.contributor.authorGuler, Ece
dc.contributor.authorTopal, Fadime
dc.contributor.authorOzcan, Gul Sinemcan
dc.contributor.authorDuruksu, Gokhan
dc.contributor.authorEce, Burak
dc.date.accessioned2024-05-19T14:38:58Z
dc.date.available2024-05-19T14:38:58Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe highly complex pathophysiology of Alzheimer's disease (AD) and the low bioavailability of the currently used drugs make it necessary to offer versatile treatment options. In this study, polyvinyl alcohol (PVA)/poly-vinylpyrrolidone (PVP) nanofibers (NFs) were loaded with rivastigmine (RIV), memantine (MM), and Gingko biloba (GB) extract, and their anti-Alzheimer's effects were investigated in vitro by cell culture and in vivo by animal experiments. The characterization studies, including FTIR, XRD, and DSC analysis, showed that the fibers exhibited a good compatibility. The rapid disintegration (in 5.2 s) and complete dissolution (in 120 s) of RIV/ MM/GB-loaded NF indicated their suitability for sublingual application. Cell viability analysis revealed that RIV/MM/GB-loaded NFs can be considered as safe and promising candidates. RIV/MM/GB-loaded NFs tremendously improved the learning and memory impairment seen in the AD model created by the injection of intracerebroventricular-streptozotocin into rats. Moreover, RIV/MM/GB-loaded NF stimulated stem cells to improve neuronal differentiation properties and significantly decreased the level of & beta;-amyloid, tau, APP, TNF-& alpha;, AChE, and GSK-3 & beta; in the brain. The histopathological and immunostaining assays demonstrated that RIV/MM/ GB-loaded NF reduced & beta;-amyloid formation and tau hyperphosphorylation in the hippocampus and cerebral cortex. Thus, a novel and promising treatment strategy could be developed that has several advantages, such as ease of sublingual administration, reduced frequency of administration associated with lower drug amounts, and finally reduced toxicity and cost.en_US
dc.description.sponsorshipTUBITAK 2209-A Research Projects Program Grant (Scientific and Technological Research Council of Turkey-TUBITAK) [1919B011903626]en_US
dc.description.sponsorshipServan Veysanoglu and Busra Ertas contributed equally to this work. This project was supported by a TUBITAK 2209-A Research Projects Program Grant (Scientific and Technological Research Council of Turkey-TUBITAK, Project Number: 1919B011903626) .en_US
dc.identifier.doi10.1016/j.jddst.2023.104691
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85164322930en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.jddst.2023.104691
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4664
dc.identifier.volume86en_US
dc.identifier.wosWOS:001037887500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectRivastigmineen_US
dc.subjectMemantineen_US
dc.subjectGingko Bilobaen_US
dc.subjectSublingual Administrationen_US
dc.titleIn vitro and in vivo evaluation of multi-target-directed Rivastigmine/Memantine/Gingko biloba-loaded nanofibers against Alzheimer's diseaseen_US
dc.typeArticleen_US

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