Postmortem biopsies of the lung, heart, liver, and spleen of COVID-19 patients

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dc.authoridMustafa Akker / 0000-0001-9140-2731
dc.authoridIşıl Yurdaışık / 0000-0001-8316-1229
dc.authorscopusidIşıl Yurdaışık / 57211471093
dc.authorwosidIşıl Yurdaışık / AAL-9433-2020
dc.authorwosidMustafa Akker / CAV-4871-2022
dc.contributor.authorYurdaışık, Işıl
dc.contributor.authorDemiröz, Ahu S.
dc.contributor.authorÖz, Aysim B.
dc.contributor.authorAkker, Mustafa
dc.contributor.authorAğırman, Ayşegül
dc.contributor.authorAksoy, Süleyman Hilmi
dc.contributor.authorNurili, Fuad
dc.date.accessioned2022-01-26T14:28:20Z
dc.date.available2022-01-26T14:28:20Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective We aimed to evaluate histopathologic alterations in the lung, heart, liver, and spleen of coronavirus 2019 (COVID-19) decedents through postmortem core needle biopsies. Materials and methods Patients who died of reverse transcription-polymerase chain reaction-proven COVID-19 were this postmortem case series. Postmortem percutaneous ultrasound-guided biopsies of the lungs, and spleen were performed using 14-and 16-gauge needles. Biopsy samples were stained with eosin and examined under a light microscope. Clinicodemographic characteristics, chest computed tomography (CT) images, and COVID-19-related treatments of the patients were also collected. Results Seven patients were included in this study. Liver and heart tissue samples were available from all and lung and spleen tissue samples were available from five and three patients, respectively. Chest images predominantly revealed bibasilar ground-glass opacities. Lung biopsies showed diffuse damage in all biopsy specimens. Heart findings were nonspecific and largely compatible with the disease. Patchy necrosis, steatosis, and mononuclear cell infiltration were the main findings in biopsies. Splenic histopathological examination showed that splenic necrosis and neutrophil infiltration were common findings in all patients. Conclusion Tissue acquisition was complete for the heart and liver and acceptable for the lungs. The amount was sufficient for a proper histopathologic examination. Histopathological findings were generally accordance with previous autopsy studies. Radiological findings of the lung were also correlated histopathologic findings. We consider that a postmortem biopsy is a feasible alternative for histopathological examinations in COVID-19 decedents.en_US
dc.identifier.citationYurdaisik, I., Demiroz, A. S., Oz, A. B., Akker, M., Agirman, A. G., Aksoy, S. H., ... & Egitim, D. C. (2021). Postmortem Biopsies of the Lung, Heart, Liver, and Spleen of COVID-19 Patients.en_US
dc.identifier.doi10.7759/cureus.20734en_US
dc.identifier.issn2168-8184en_US
dc.identifier.issue13en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.20734
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2424
dc.identifier.volume13en_US
dc.identifier.wosWOS:000737108100016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYurdaışık, Işıl
dc.institutionauthorAkker, Mustafa
dc.language.isoenen_US
dc.publisherCUREUS INCen_US
dc.relation.ispartofCUREUS JOURNAL OF MEDICAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpleensars-Cov-2en_US
dc.subjectPostmortemen_US
dc.subjectLungen_US
dc.subjectLiveren_US
dc.subjectHistopathologicen_US
dc.subjectHearten_US
dc.subjectCovid-19en_US
dc.subjectBiopsyen_US
dc.titlePostmortem biopsies of the lung, heart, liver, and spleen of COVID-19 patientsen_US
dc.typeArticleen_US

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