Gut bacteria after recovery from COVID-19: a pilot study

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dc.authorscopusidHakan Şentürk / 35320276300en_US
dc.authorwosidHakan Şentürk / JPP-4887-2023en_US
dc.contributor.authorPolo P.G.
dc.contributor.authorÇolak-Al B.
dc.contributor.authorRafiqi, A. Matteen
dc.contributor.authorŞentürk, Hakan
dc.date.accessioned2023-01-19T08:31:43Z
dc.date.available2023-01-19T08:31:43Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: COVID-19 has been a major infectious disease lately in humans. 10% of people experience persistent symptoms twelve weeks after having COVID-19. The gut microbiota is essential for host immunity. Thus, gut microbiota composition may contribute to the recovery of COVID-19 patients. The impact of COVID-19 on the gut microbiota of patients during recovery is less explored. We investigated the potential alterations of bacterial gut microbiota of immediately recovered COVID-19 patients, and six months after their recovery. MATERIALS AND METHODS: Stool samples were collected from 8 patients with COVID-19 immediately after their recovery, and six months after SARS-CoV-2 clearance, as well as from 8 healthy donors as a control group. 16S rRNA gene sequencing was performed to analyze the correlation between disease recovery and microbiota using the immediately recovered and control group. Specific primers were designed for the most significantly altered bacteria and used to analyze the changes in intestinal microbiota composition of patients using qPCR. qPCR comparisons were performed on three groups: newly recovered from COVID-19, after six months of COVID-19 recovery, and healthy controls. RESULTS: Compared with the healthy control group, patients who immediately recovered from COVID-19 had significantly less presence of 15 bacterial groups. The immediately recovered patients had a very significantly higher relative abundance of the opportunistic pathogen Mycolicibacterium. No differences were found between the immediately recovered patients, and after six months of recovery using the qPCR analyses. CONCLUSIONS: Our results contribute novel insights regarding the alteration of human gut microbiota and the emergence of opportunistic pathogens in recovered patients of COVID-19. Further studies with a larger experimental size are needed to reveal balance or dysbiosis in patients after COVID-19 recovery. © 2022 Verduci Editore s.r.l. All rights reserved.en_US
dc.identifier.citationPolo, P. G., Çolak-Al, B., Sentürk, H., & Rafiqi, A. M. (2022). Gut bacteria after recovery from COVID-19: a pilot study. European Review for Medical and Pharmacological Sciences, 26(22), 8599-8611.en_US
dc.identifier.doi10.26355/eurrev_202211_30397en_US
dc.identifier.endpage8611en_US
dc.identifier.issn1128-3602en_US
dc.identifier.issue22en_US
dc.identifier.pmid36459041en_US
dc.identifier.scopus2-s2.0-85143278599en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage8599en_US
dc.identifier.urihttp://doi.org/10.26355/eurrev_202211_30397
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3825
dc.identifier.volume26en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorŞentürk, Hakan
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDysbiosisen_US
dc.subjectInfectious Diseaseen_US
dc.subjectIntestinal Microbiotaen_US
dc.subjectLong COVIDen_US
dc.subjectMycolicibacteriumen_US
dc.subjectOpportunistic Pathogenen_US
dc.titleGut bacteria after recovery from COVID-19: a pilot studyen_US
dc.typeArticleen_US

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