Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells

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dc.contributor.authorAy, Ebru Nur
dc.contributor.authorCaner, Armagan
dc.contributor.authorHepokur, Ceylan Ozsoy
dc.contributor.authorKalindemirtas, Ferdane Danisman
dc.contributor.authorEroglu, Gunes Ozen
dc.contributor.authorKariper, I. Afsin
dc.date.accessioned2024-05-19T14:39:38Z
dc.date.available2024-05-19T14:39:38Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various methods were used to characterize the surface and morphology of propolis nanoparticles (NP-Pro), including UV-VIS, FTIR, DLS, and EDX-SEM. The cytotoxic activity of MCF-7, MDA-MB-231 breast cancer cells was measured by XTT technique and compared with healthy cells (MCF-10A). The apoptotic effect of NP-Pro was assessed by flow cytometry using Annexin/PI. The IC50 values of NP-Pro on MCF-7, MDA-MB-231 and MCF-10A cells were 13.67 +/- 0.89, 17.89 +/- 0.6, 29.9 +/- 0.56 mu g, respectively. According to these findings, the NP-Pro form we prepared was more cytotoxic on cancer cells than propolis. Cancer cells had much stronger apoptotic activity than healthy cells (p < 0.0001). In this work, NP-Pro was produced through a distinct, straightforward, and low-cost method. In summary, the NP-Pro we synthesized may be a promising potential agent for breast cancer treatment due to its specific cytotoxicity via apoptosis.en_US
dc.identifier.doi10.1080/16583655.2023.2249628
dc.identifier.issn1658-3655
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85169338983en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org10.1080/16583655.2023.2249628
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4819
dc.identifier.volume17en_US
dc.identifier.wosWOS:001058307900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Taibah University For Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBreast Canceren_US
dc.subjectPropolisen_US
dc.subjectNanoparticleen_US
dc.subjectCytotoxicityen_US
dc.titlePropolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cellsen_US
dc.typeArticleen_US

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