Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells

dc.contributor.authorAy, Ebru Nur
dc.contributor.authorCaner, Armagan
dc.contributor.authorHepokur, Ceylan Ozsoy
dc.contributor.authorKalindemirtas, Ferdane Danisman
dc.contributor.authorEroglu, Gunes Ozen
dc.contributor.authorKariper, I. Afsin
dc.date.accessioned2024-05-19T14:39:38Z
dc.date.available2024-05-19T14:39:38Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various methods were used to characterize the surface and morphology of propolis nanoparticles (NP-Pro), including UV-VIS, FTIR, DLS, and EDX-SEM. The cytotoxic activity of MCF-7, MDA-MB-231 breast cancer cells was measured by XTT technique and compared with healthy cells (MCF-10A). The apoptotic effect of NP-Pro was assessed by flow cytometry using Annexin/PI. The IC50 values of NP-Pro on MCF-7, MDA-MB-231 and MCF-10A cells were 13.67 +/- 0.89, 17.89 +/- 0.6, 29.9 +/- 0.56 mu g, respectively. According to these findings, the NP-Pro form we prepared was more cytotoxic on cancer cells than propolis. Cancer cells had much stronger apoptotic activity than healthy cells (p < 0.0001). In this work, NP-Pro was produced through a distinct, straightforward, and low-cost method. In summary, the NP-Pro we synthesized may be a promising potential agent for breast cancer treatment due to its specific cytotoxicity via apoptosis.en_US
dc.identifier.doi10.1080/16583655.2023.2249628
dc.identifier.issn1658-3655
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85169338983en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org10.1080/16583655.2023.2249628
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4819
dc.identifier.volume17en_US
dc.identifier.wosWOS:001058307900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Taibah University For Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBreast Canceren_US
dc.subjectPropolisen_US
dc.subjectNanoparticleen_US
dc.subjectCytotoxicityen_US
dc.titlePropolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cellsen_US
dc.typeArticleen_US

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