Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells
dc.contributor.author | Ay, Ebru Nur | |
dc.contributor.author | Caner, Armagan | |
dc.contributor.author | Hepokur, Ceylan Ozsoy | |
dc.contributor.author | Kalindemirtas, Ferdane Danisman | |
dc.contributor.author | Eroglu, Gunes Ozen | |
dc.contributor.author | Kariper, I. Afsin | |
dc.date.accessioned | 2024-05-19T14:39:38Z | |
dc.date.available | 2024-05-19T14:39:38Z | |
dc.date.issued | 2023 | |
dc.department | İstinye Üniversitesi | en_US |
dc.description.abstract | The aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various methods were used to characterize the surface and morphology of propolis nanoparticles (NP-Pro), including UV-VIS, FTIR, DLS, and EDX-SEM. The cytotoxic activity of MCF-7, MDA-MB-231 breast cancer cells was measured by XTT technique and compared with healthy cells (MCF-10A). The apoptotic effect of NP-Pro was assessed by flow cytometry using Annexin/PI. The IC50 values of NP-Pro on MCF-7, MDA-MB-231 and MCF-10A cells were 13.67 +/- 0.89, 17.89 +/- 0.6, 29.9 +/- 0.56 mu g, respectively. According to these findings, the NP-Pro form we prepared was more cytotoxic on cancer cells than propolis. Cancer cells had much stronger apoptotic activity than healthy cells (p < 0.0001). In this work, NP-Pro was produced through a distinct, straightforward, and low-cost method. In summary, the NP-Pro we synthesized may be a promising potential agent for breast cancer treatment due to its specific cytotoxicity via apoptosis. | en_US |
dc.identifier.doi | 10.1080/16583655.2023.2249628 | |
dc.identifier.issn | 1658-3655 | |
dc.identifier.issue | 1 | en_US |
dc.identifier.scopus | 2-s2.0-85169338983 | en_US |
dc.identifier.scopusquality | N/A | en_US |
dc.identifier.uri | https://doi.org10.1080/16583655.2023.2249628 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12713/4819 | |
dc.identifier.volume | 17 | en_US |
dc.identifier.wos | WOS:001058307900001 | en_US |
dc.identifier.wosquality | N/A | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.relation.ispartof | Journal of Taibah University For Science | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.snmz | 20240519_ka | en_US |
dc.subject | Breast Cancer | en_US |
dc.subject | Propolis | en_US |
dc.subject | Nanoparticle | en_US |
dc.subject | Cytotoxicity | en_US |
dc.title | Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells | en_US |
dc.type | Article | en_US |