Oral Microbiota Signatures in the Pathogenesis of Euthyroid Hashimoto's Thyroiditis

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dc.authoridDemirci, Mehmet/0000-0001-9670-2426
dc.authoridUnlu, Ozge/0000-0002-5411-5925
dc.authoridKaris, Denizhan/0000-0002-5976-4107
dc.authoridErdem, Mustafa Genco/0000-0002-7783-8130
dc.authorwosidDemirci, Mehmet/O-1886-2015
dc.authorwosidUnlu, Ozge/P-5191-2018
dc.authorwosidKaris, Denizhan/N-5001-2019
dc.authorwosidErdem, Mustafa Genco/S-2964-2017
dc.contributor.authorErdem, Mustafa Genco
dc.contributor.authorUnlu, Ozge
dc.contributor.authorAtes, Fatma
dc.contributor.authorKaris, Denizhan
dc.contributor.authorDemirci, Mehmet
dc.date.accessioned2024-05-19T14:39:13Z
dc.date.available2024-05-19T14:39:13Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractOne of the most prevalent autoimmune illnesses in the world is Hashimoto's thyroiditis, whose pathogenesis is still unknown. The gut-thyroid axis is frequently examined, and although oral health affects thyroid functions, there are limited data on how oral microbiota is linked to Hashimoto's thyroiditis. The study aims to identify the oral microbiota from saliva samples taken from treated (with levothyroxine) and untreated female euthyroid Hashimoto's thyroiditis patients as well as healthy controls who were age- and sex-matched to compare the oral microbiota across the groups and to contribute preliminary data to the literature. This study was designed as a single-center cross-sectional observational study. Sixty (60) female patients with euthyroid Hashimoto's thyroiditis (HT) and eighteen (18) age- and gender-matched healthy controls were included in this study. Unstimulated saliva samples were collected. After DNA isolation, sequencing was performed by targeting the V3-V4 gene regions of the 16S rRNA on the MiSeq instrument. R scripts and SPSS were used for bioinformatic and statistical analysis. No significant differences were found in the diversity indices. However, Patescibacteria phylum showed a significantly higher abundance (3.59 vs. 1.12; p = 0.022) in the oral microbiota of HT patients compared to HC. In the oral microbiota, the euthyroid HT group had approximately 7, 9, and 10-fold higher levels of the Gemella, Enterococcus, and Bacillus genera levels than healthy controls, respectively. In conclusion, the results of our study demonstrated that Hashimoto's thyroiditis causes changes in the oral microbiota, whereas the medicine used to treat the condition had no such effects. Therefore, revealing the core oral microbiota and long-term follow-up of the HT process by conducting extensive and multicenter studies might provide some important data for understanding the pathogenesis of the disease.en_US
dc.description.sponsorshipBeykent University [2021-2022-BAP-02]en_US
dc.description.sponsorshipThis research was funded by Beykent University, grant number 2021-2022-BAP-02.en_US
dc.identifier.doi10.3390/biomedicines11041012
dc.identifier.issn2227-9059
dc.identifier.issue4en_US
dc.identifier.pmid37189630en_US
dc.identifier.urihttps://doi.org10.3390/biomedicines11041012
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4729
dc.identifier.volume11en_US
dc.identifier.wosWOS:000977120000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofBiomedicinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAutoimmunityen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.subjectOral Microbiotaen_US
dc.titleOral Microbiota Signatures in the Pathogenesis of Euthyroid Hashimoto's Thyroiditisen_US
dc.typeArticleen_US

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