A randomized controlled trial of combined low-intensity extracorporeal shockwave therapy and Dapoxetine use in the management of lifelong premature ejaculation

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dc.contributor.authorDogan, Kazim
dc.contributor.authorTaskiran, Mehmet
dc.date.accessioned2024-05-19T14:46:17Z
dc.date.available2024-05-19T14:46:17Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractWe aimed to evaluate the efficacy of combined low-intensity extracorporeal shockwave therapy (LI-ESWT) and dapoxetine administration for the treatment of lifelong premature ejaculation (LPE) in comparison to LI-ESWT and dapoxetine alone. In the randomized controlled trial, 212 men diagnosed with LPE were enrolled. The participants were randomized into four subgroups: control (n = 50), dapoxetine (n = 56), LI-ESWT (n = 50) and LI-ESWT + dapoxetine (n = 56). The intravaginal ejaculation latency (IELT), premature ejaculation profile (PEP), and Global Impression of Change (GIC) were evaluated. There were substantial improvements in the fold-increase of the IELT (F-IELT), and PEP and GIC-I scores in both the dapoxetine (p < 0.001) and LI-ESWT + Dapoxetine (p < 0.001) groups than in the control and LI-ESWT groups. Although the LI-ESWT group demonstrated a minor improvement in the F-IELT score (p = 0.04), there were no noticeable improvements in the PEP (p = 0.12) and GIC-I ( p = 0.15) scores. In conclusion, a combination of dapoxetine administration and LI-ESWT might be more effective in treating LPE than LI-ESWT or dapoxetine alone, indicating a potential synergistic effect.en_US
dc.identifier.doi10.22514/jomh.2023.076
dc.identifier.endpage98en_US
dc.identifier.issn1875-6867
dc.identifier.issn1875-6859
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85170282269en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org10.22514/jomh.2023.076
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5487
dc.identifier.volume19en_US
dc.identifier.wosWOS:001072161600011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMre Pressen_US
dc.relation.ispartofJournal of Mens Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPremature Ejaculationen_US
dc.subjectTherapyen_US
dc.subjectDapoxetineen_US
dc.subjectLi-Eswten_US
dc.subjectIelten_US
dc.titleA randomized controlled trial of combined low-intensity extracorporeal shockwave therapy and Dapoxetine use in the management of lifelong premature ejaculationen_US
dc.typeArticleen_US

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