A Stem Cell and Tissue Engineering Perspective on Microfluidic Chips

Küçük Resim Yok

Tarih

2024

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Gazi Univ

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Microfluidic systems, which can be easily modified and integrated into many studies, have been the focus of attention of researchers in recent years. Thanks to microfluidic chips, controlled and optimized cell culture studies can be performed with less solution and continuous perfusion. In recent years, culturing the stem cells which has attracted the attention of regenerative medicine, alone or together with other cells and differentiating these cells in the desired direction, are frequently studied in chip systems. Adding hydrogels or decellularized organ matrices to these systems that will mimic the intercellular environment conditions gives results closer to in vivo. There are many studies showing that all the behaviors of the stem cells, including the differentiation, change considerably due to the material from which the chips are produced, the surface modifications, the flow rate, the medium content, the mechano-chemical properties of the hydrogels used, and electrical, chemical or mechanical stimulations. It is predicted that microfluidic chip systems will add a new dimension to personalized medicine, drug toxicity experiments, point-of-care rapid diagnostic kits, and many basic science researches in the future, and will be one of the more reliable and inexpensive potential methods, especially by replacing animal experiments. All these reasons make chip systems the focus of research. In this study; The fabrication, advantages, disadvantages, and applications of microfluidic chip systems in tissue engineering are discussed.

Açıklama

Anahtar Kelimeler

Microfluidic Systems, Lab-On-Chip, Organ-On-Chip, Tissue Engineering, Stem Cell

Kaynak

Journal of Polytechnic-Politeknik Dergisi

WoS Q Değeri

N/A

Scopus Q Değeri

Cilt

27

Sayı

2

Künye