A Stem Cell and Tissue Engineering Perspective on Microfluidic Chips

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dc.authoridTorkay, Gülşah/0000-0002-6803-494X
dc.authorwosidTorkay, Gülşah/IUP-3797-2023
dc.contributor.authorTorkay, Guelsah
dc.contributor.authorOeztuerk, Ayca Bal
dc.date.accessioned2024-05-19T14:45:49Z
dc.date.available2024-05-19T14:45:49Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMicrofluidic systems, which can be easily modified and integrated into many studies, have been the focus of attention of researchers in recent years. Thanks to microfluidic chips, controlled and optimized cell culture studies can be performed with less solution and continuous perfusion. In recent years, culturing the stem cells which has attracted the attention of regenerative medicine, alone or together with other cells and differentiating these cells in the desired direction, are frequently studied in chip systems. Adding hydrogels or decellularized organ matrices to these systems that will mimic the intercellular environment conditions gives results closer to in vivo. There are many studies showing that all the behaviors of the stem cells, including the differentiation, change considerably due to the material from which the chips are produced, the surface modifications, the flow rate, the medium content, the mechano-chemical properties of the hydrogels used, and electrical, chemical or mechanical stimulations. It is predicted that microfluidic chip systems will add a new dimension to personalized medicine, drug toxicity experiments, point-of-care rapid diagnostic kits, and many basic science researches in the future, and will be one of the more reliable and inexpensive potential methods, especially by replacing animal experiments. All these reasons make chip systems the focus of research. In this study; The fabrication, advantages, disadvantages, and applications of microfluidic chip systems in tissue engineering are discussed.en_US
dc.identifier.doi10.2339/politeknik.1094010
dc.identifier.issn1302-0900
dc.identifier.issn2147-9429
dc.identifier.issue2en_US
dc.identifier.urihttps://doi.org10.2339/politeknik.1094010
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5356
dc.identifier.volume27en_US
dc.identifier.wosWOS:001025996800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGazi Univen_US
dc.relation.ispartofJournal of Polytechnic-Politeknik Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMicrofluidic Systemsen_US
dc.subjectLab-On-Chipen_US
dc.subjectOrgan-On-Chipen_US
dc.subjectTissue Engineeringen_US
dc.subjectStem Cellen_US
dc.titleA Stem Cell and Tissue Engineering Perspective on Microfluidic Chipsen_US
dc.typeArticleen_US

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