Biological Activities of the Natural Coumarins from Apiaceae Plants

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dc.authoridMihoglugil, Feyyaz/0000-0003-0976-0244
dc.authorwosidMihoglugil, Feyyaz/JCP-0712-2023
dc.contributor.authorTosun, Fatma
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorKaradag, Ayse Esra
dc.contributor.authorMihoglugil, Feyyaz
dc.contributor.authorAkalgan, Demet
dc.contributor.authorMiski, Mahmut
dc.date.accessioned2024-05-19T14:40:29Z
dc.date.available2024-05-19T14:40:29Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractNineteen natural coumarins; badrakemin (1), colladonin (2), 14'-acetoxybadrakemin (3), anatolicin (4), 14'-hydroxycolladonin (5), badrakemone (6), karatavicinol (7), 14'-acetoxybadrakemone (8), 14'-acetoxycolladonin (9), colladonin acetate (10), deltoin (11), smyrnioridin (12), isoimperatorin (13), oxypeucedanin (14), bergapten (15), osthol (16), 4'-senecioyloxyostol (17), neopapillarine (18), and scoparone (19) were tested against U87MG, A549, and PC3 cancer cell lines as well as against healthy human embryonic kidney cell line, HEK293. Colladonin (2) was found to have IC50 values of 12.6 and 11.58 & mu;M in A549 and PC3 cell lines, respectively. Deltoin (11) and 14'-acetoxybadrakemin (3) were found to have an IC50 value of 9.92 & mu;M and 11.85 & mu;M against the U87MG cell line, respectively. Remarkably, these compounds show very low cytotoxicity against the healthy human embryonic kidney cell line, HEK293. In addition to the cytotoxic activity, nineteen natural coumarins were tested for their inhibitory activity against 5-LOX, collagenase, and elastase enzymes.& COPY; 2023 ACG Publications. All rights reserveden_US
dc.identifier.doi10.6135/rnp.396.2304.2758
dc.identifier.issn1307-6167
dc.identifier.scopus2-s2.0-85171361349en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org10.6135/rnp.396.2304.2758
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4969
dc.identifier.wosWOS:001015042100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofRecords of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCoumarinen_US
dc.subjectCytotoxicityen_US
dc.subjectCollagenaseen_US
dc.subjectElastaseen_US
dc.subjectLipoxygenaseen_US
dc.titleBiological Activities of the Natural Coumarins from Apiaceae Plantsen_US
dc.typeArticleen_US

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