Discussing the roles of proline and glycine from the perspective of cold adaptation in lipases and cellulases

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dc.authoridSinem Fırtına / 0000-0002-3370-8545en_US
dc.authoridAslı Kutlu / 0000-0002-9169-388X
dc.authorscopusidSinem Fırtına / 16642650000
dc.authorscopusidAslı Kutlu / 57716458200
dc.authorwosidSinem Fırtına / X-8520-2018en_US
dc.authorwosidAslı Kutlu / AGG-7405-2022
dc.contributor.authorÖten, Ahmet Melih
dc.contributor.authorAtak, Evren
dc.contributor.authorKaraca, Banu Taktak
dc.contributor.authorFırtına, Sinem
dc.contributor.authorKutlu, Aslı
dc.date.accessioned2022-11-08T12:48:37Z
dc.date.available2022-11-08T12:48:37Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractLipases and cellulases have been extensively used in the field of biotechnology for varied purposes. Mainly, the ongoing researches focus on the improvements of kinetic and enzymatic characteristics of enzymes to meet industrial needs. With the discovery of psychrophilic cellulase and lipase sources, a new era has opened for protein research by allowing the discovery of novel functions together with the description of unique cold adaptation mechanisms to harsh environments. The ability of cold-adapted lipase and cellulases to enable chemical reactions at lower temperatures provides a great opportunity to cut the cost of the finished product by lowering energy and purifying expanses. The advances in the cold-adapted lipase and cellulase enzymes are the cumulative efforts of organic chemists, biophysicists, biotechnologists, and process engineers who greatly contribute to a better understanding of cold-adaptation phenomena from different points of view. In this review, we cover the cold-adaptation aspects of cellulase and lipase enzymes from structural points of view by referring to the roles of Gly and Pro residues. Gly and Pro residues accelerate the cold-adaptation of enzymes by altering the conformational changes in the 3 D structure of proteins The list of microorganisms as a source of cold-adapted cellulases and lipases is given by referring to biotechnological applications. After introducing the thermodynamic background of Gly and Pro residues in the phenomena of cold-adaptation, specific examples are given to emphasise how introducing Gly and Pro into 3 D structure of protein molecules adds value in terms of biotechnological application by contributing to cold-adaptationen_US
dc.identifier.citationÖten, A. M., Atak, E., Taktak Karaca, B., Fırtına, S., & Kutlu, A. (2022). Discussing the roles of proline and glycine from the perspective of cold adaptation in lipases and cellulases. Biocatalysis and Biotransformation, 1-18.en_US
dc.identifier.doi10.1080/10242422.2022.2124111en_US
dc.identifier.issn1024-2422en_US
dc.identifier.issn1029-2446en_US
dc.identifier.scopus2-s2.0-85141099954en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/10242422.2022.2124111
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3253
dc.identifier.wosWOS:000870900900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorFırtına, Sinem
dc.institutionauthorKutlu, Aslı
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCISen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCold-adaptationen_US
dc.subjectGlycineen_US
dc.subjectProlineen_US
dc.subjectCellulaseen_US
dc.subjectLipaseen_US
dc.titleDiscussing the roles of proline and glycine from the perspective of cold adaptation in lipases and cellulasesen_US
dc.typeReview Articleen_US

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