Pathogens in Pediatric Septic Arthritis: A Multi-Center Study in Turkiye (PEDSART Study)

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dc.authoridKARA, ATES/0000-0002-1654-3232
dc.authoridSutcu, Murat/0000-0002-2078-9796
dc.authoridYesil, Edanur/0000-0002-8926-9959
dc.authoridÖNCEL, Selim/0000-0002-5493-1818
dc.authoridKılıç Çil, Merve/0000-0002-0924-5739
dc.authoridCetin, Benhur Sirvan/0000-0002-8470-4907
dc.authoridKUYUCU, NECDET/0000-0002-6721-4105
dc.authorwosidiseri nepesov, merve/JEZ-9887-2023
dc.authorwosidKARA, ATES/I-9081-2013
dc.authorwosidSutcu, Murat/AAR-5212-2020
dc.authorwosidYesil, Edanur/GSO-3630-2022
dc.authorwosidAygun, Deniz/AAC-9239-2021
dc.authorwosidÖNCEL, Selim/A-7286-2013
dc.authorwosidKılıç Çil, Merve/HNS-1622-2023
dc.contributor.authorNepesov, Merve Iseri
dc.contributor.authorKilic, Omer
dc.contributor.authorSali, Enes
dc.contributor.authorYesil, Edanur
dc.contributor.authorAkar, Asuman
dc.contributor.authorKaman, Ayse
dc.contributor.authorAkcan, Ozge Metin
dc.date.accessioned2024-05-19T14:46:37Z
dc.date.available2024-05-19T14:46:37Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, and therapeutic approach of SA in children in Turkiye, emphasizing the role of real-time polymerase chain reaction (PCR) techniques in the diagnosis. Methods: In this multi-center, prospective study, children hospitalized due to SA between February 2018 and July 2020 in 23 hospitals in 14 cities in Turkiye were included. Clinical, demographic, laboratory, and radiological findings were assessed, and real-time PCR was performed using synovial fluid samples. Results: Seventy-five children aged between 3 and 204 months diagnosed with acute SA were enrolled. Joint pain was the main complaint at admission, and the most commonly involved joints were the knees in 58 patients (77.4%). The combination of synovial fluid culture and real-time PCR detected causative bacteria in 33 patients (44%). In 14 (18.7%) patients, the etiological agent was demonstrated using only PCR. The most commonly isolated etiologic agent was Staphylococcus aureus, which was detected in 22 (29.3%) patients, while Streptococcus pyogenes was found in 4 (5.3%) patients and Kingella kingae in 3 (4%) patients. Streptococcus pyogenes and Kingella kingae were detected using only PCR. Most patients (81.3%) received combination therapy with multiple agents, and the most commonly used combination was glycopeptides plus third-generation cephalosporin. Conclusions: Staphylococcus aureus is the main pathogen in pediatric SA, and with the use of advanced diagnostic approaches, such as real-time PCR, the chance of diagnosis increases, especially in cases due to Kingella kingae and Streptococcus pyogenes.en_US
dc.description.sponsorshipScientific Research Projects of Eskisehir Osmangazi University [2019/11052]en_US
dc.description.sponsorshipThe study was supported financially by the Scientific Research Projects of Eskisehir Osmangazi University (2019/11052).en_US
dc.identifier.doi10.3390/children11010134
dc.identifier.issn2227-9067
dc.identifier.issue1en_US
dc.identifier.pmid38275444en_US
dc.identifier.urihttps://doi.org10.3390/children11010134
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5561
dc.identifier.volume11en_US
dc.identifier.wosWOS:001194982100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofChildren-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectSeptic Arthritisen_US
dc.subjectChildrenen_US
dc.subjectPolymerase Chain Reactionen_US
dc.titlePathogens in Pediatric Septic Arthritis: A Multi-Center Study in Turkiye (PEDSART Study)en_US
dc.typeArticleen_US

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