Hematological neoplastic disorders with chromosome 3 abnormalities

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dc.authoridSüreyya Bozkurt / 0000-0002-1765-9894en_US
dc.authoridFiliz Yarımcan Sağlam / 0000-0001-8267-0435
dc.authorscopusidSüreyya Bozkurt / 55540860700
dc.authorscopusidFiliz Yarımcan Sağlam / IWD-5094-2023
dc.authorwosidSüreyya Bozkurt / AAP-1146-2020
dc.authorwosidFiliz Yarımcan Sağlam / 57199153940
dc.contributor.authorBozkurt, Süreyya
dc.contributor.authorOkay, Mufide
dc.contributor.authorSağlam Yarımcan, Filiz
dc.contributor.authorHaznedaroğlu, Celalettin İbrahim
dc.date.accessioned2020-08-30T20:07:03Z
dc.date.available2020-08-30T20:07:03Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Conventional karyotyping in the patients with haematological malignancies is very important. Because chromosomal abnormalities which detected in these patients have diagnostic and prognostic value. Aim: The aim of this study was to assess the patients with hematologic malignancy having chromosome 3 abnormalities which are rare. Method: Conventional cytogenetic analysis were done from bone marrow samples of patients. Samples were treated with trypsin and stained with Giemsa (GTG banding). 20 metaphases of each patient were examined and karyotypes were formed. Results: Among the 6865 patients analysed via conventional cytogenetic methods, 701 (10.2%) were found as pathological and 39 (5.5%) of those were found to have chromosome 3 abnormalities. The most common neoplastic diseases observed in patients which have chromosomes 3 abnormalities were Multiple Myeloma and Acute Myeloid Leukaemia (25.6% each), Myelodysplastic Syndrome (20.5%), Acute Lymphoblastic Leukaemia (12.8%), Lymphoma (12.8%) and Chronic Lymphoblastic Leukaemia (2.6%). Numerical chromosomes 3 abnormalities were 53.8% and structural chromosomal abnormalities were 43.5%. Complex karyotypes were 87.1% of all chromosome 3 abnormalities in our group. Conclusion: Chromosome 3 anomalies are seen less frequently in hematologic malignancies. Patients have both numerical and structural chromosome 3 anomalies and these anomalies are mostly found in complex karyotype. With 76.6% mortality rate, in our group chromosome 3 abnormalities were found to relate with unfavorable prognosis.en_US
dc.identifier.citationBozkurt, S., Okay, M., Saglam, F., & Haznedaroglu, C. I. (2019). HEMATOLOGICAL NEOPLASTIC DISORDERS WITH CHROMOSOME 3 ABNORMALITIES. ACTA MEDICA MEDITERRANEA, 35(5), 2703–2707. https://doi.org/10.19193/0393-6384_2019_5_425en_US
dc.identifier.doi10.19193/0393-6384_2019_5_425en_US
dc.identifier.endpage2707en_US
dc.identifier.issn0393-6384en_US
dc.identifier.issn2283-9720en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85071887003en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2703en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2019_5_425
dc.identifier.urihttps://hdl.handle.net/20.500.12713/685
dc.identifier.volume35en_US
dc.identifier.wosWOS:000484062400068en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBozkurt, Süreyyaen_US
dc.institutionauthorSağlam Yarımcan, Filiz
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematological Canceren_US
dc.subjectChromosome 3 Abnormalitiesen_US
dc.subjectCancer Cytogeneticen_US
dc.subjectConventional Karyotypingen_US
dc.titleHematological neoplastic disorders with chromosome 3 abnormalitiesen_US
dc.typeArticleen_US

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