A focusing study on radioprotective and antioxidant effects of Annona muricata leaf extract in the circulation and liver tissue: clinical and experimental studies

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dc.authoridHüseyin Ozan Tekin / 0000-0002-0997-3488en_US
dc.authorscopusidHüseyin Ozan Tekin / 56971130700en_US
dc.authorwosidHüseyin Ozan Tekin / J-9611-2016en_US
dc.contributor.authorElmas, Özlem
dc.contributor.authorŞahin, Havva Hande Keser
dc.contributor.authorGüven, Berrak
dc.contributor.authorAbuzaid, Mohamed M.
dc.contributor.authorElshami, Wiam
dc.contributor.authorAlmisned, Ghada
dc.contributor.authorZakaly, Hesham M. H.
dc.contributor.authorEne, Antoaneta
dc.contributor.authorTekin, Hüseyin Ozan
dc.date.accessioned2022-11-07T07:44:02Z
dc.date.available2022-11-07T07:44:02Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümüen_US
dc.description.abstractObjectives: This study investigates the effect of Annona muricata (AM) leaf extract against irradiation-induced damage by the evaluation of hepatic tissue and the levels of oxidative and inflammatory stress in the circulation. Methods: An experimental study with 37 female Wistar albino rats randomized into four groups (controls and three intervention groups) was performed. The first interventional group (group 2) received 300 mg/kg of AM leaf extract by oral gavage once a day for 9 days, group 3 received a single dose of whole-body radiation (8.3 Gy) after a 9-day oral gavage treatment with saline, and the last group received the same irradiation of 8.3 Gy after being treated with 300 mg/kg of AM leaf extract by oral gavage once a day for 9 days. Results: Radiation was found to elevate reactive oxygen species parameters, and AM administration before irradiation was found to decrease total oxidant status (TOS), increase caspase 9, and improve hepatic damage when compared with the group that received only irradiation. Conclusion: The damage caused by irradiation may be ameliorated by the use of the AM extract, which appears to be effective in preventing oxidative stress and inflammatory activity.en_US
dc.identifier.citationElmas, O., Sahin, H. H. K., Guven, B., Abuzaid, M. M., Elshami, W., Almisned, G., . . . Tekin, H. O. (2022). A focusing study on radioprotective and antioxidant effects of annona muricata leaf extract in the circulation and liver tissue: Clinical and experimental studies. Open Chemistry, 20(1), 920-928. doi:10.1515/chem-2022-0206en_US
dc.identifier.doi10.1515/chem-2022-0206en_US
dc.identifier.endpage928en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85139254835en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage920en_US
dc.identifier.urihttps://doi.org/10.1515/chem-2022-0206
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3248
dc.identifier.volume20en_US
dc.identifier.wosWOS:000858430000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTekin, Hüseyin Ozan
dc.language.isoenen_US
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofOpen Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnnona Muricataen_US
dc.subjectApoptosisen_US
dc.subjectIrradiationen_US
dc.subjectOxidative Stressen_US
dc.subjectRadioprotectiveen_US
dc.titleA focusing study on radioprotective and antioxidant effects of Annona muricata leaf extract in the circulation and liver tissue: clinical and experimental studiesen_US
dc.typeArticleen_US

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