Comparison of resolvin D1 levels in patients with aneurysmal subarachnoid haemorrhage with those in healthy controls

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dc.authoridTufan Hiçdönmez / 0000-0003-4847-8727en_US
dc.authorscopusidTufan Hiçdönmez / 6603448174
dc.authorwosidTufan Hiçdönmez / GME-0060-2022en_US
dc.contributor.authorHiçdönmez, Tufan
dc.contributor.authorAydoğmuş, Evren
dc.contributor.authorKendirlioğlu, Bekir Can
dc.date.accessioned2022-07-05T14:16:11Z
dc.date.available2022-07-05T14:16:11Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The literature points to the role of neuroinflammation in the aetiology of vasospasm, which is the leading cause of mortality and morbidity after aneurysmal subarachnoid haemorrhage. Neuroinflammation has been found to contribute to early and delayed brain injury, both of which are associated with poor clinical outcomes. Resolvin D1 is hypothesised to have a protective effect on neurons against apoptosis and has anti-inflammatory and pro-resolving effects on the neuroinflammation and vasospasm after aneurysmal subarachnoid haemorrhage. In this study, we aimed to investigate the serum resolvin D1 levels and its possible relationship with vasospasm and inflammatory markers, such as C-reactive protein, neutrophil and albumin in patients with aneurysmal subarachnoid haemorrhage. Methods: Fifteen patients with spontaneous aneurysmal subarachnoid haemorrhage between June 2017 and May 2018 presenting at our institution were included in the study. Their data were compared with those of 17 healthy volunteers. Patients with aneurysmal subarachnoid haemorrhage were divided into two groups: the subarachnoid haemorrhage with vasospasm group (8 patients), which included patients with subarachnoid haemorrhage and angiographic vasospasm , and subarachnoid haemorrhage without vasospasm group (7 patients), which included patients with subarachnoid haemorrhage without angiographic vasospasm. Serial serum resolvin D1 measurements were taken on days 1, 4, 9 and 14 after subarachnoid haemorrhage. Results: Resolvin D1 levels were statistically significantly higher on day 1 after subarachnoid haemorrhage in patients with angiographic vasospasm (p=0.021). Additionally, in the group with angiographic vasospasm, all the measured resolvin D1 values were also higher compared to other groups. The measurements of serum C-reactive protein and neutrophil levels were found to be statistically significantly higher on day 1 after subarachnoid haemorrhage in both groups compared to the control group. Conclusion: Resolvin D1 levels tend to increase secondary to inflammation because of its neuroprotective and anti-inflammatory properties. Thus, high resolvin D1levels in the subarachnoid haemorrhage + vasospasm group indicated that inflammatory processes play a role in the aetiopathogenesis of angiographic vasospasm after aneurysmal subarachnoid haemorrhage. Consequently, resolvin D1 might be an important biomarker in the prediction of the angiographic vasospasm after aneurysmal subarachnoid haemorrhage.en_US
dc.identifier.citationKENDİRLİOĞLU B. C,AYDOĞMUŞ E,HİÇDÖNMEZ T (2021). Comparison of Resolvin D1 Levels in Patients with Aneurysmal Subarachnoid Haemorrhage with Those in Healthy Controls. Southern Clinics of Istanbul Eurasia, 32(3), 273 - 279. Doi: 10.14744/scie.2021.46036en_US
dc.identifier.doi10.14744/scie.2021.46036en_US
dc.identifier.endpage279en_US
dc.identifier.issn2587-0998en_US
dc.identifier.issue3en_US
dc.identifier.startpage273en_US
dc.identifier.trdizinid523817en_US
dc.identifier.urihttp://doi.org/10.14744/scie.2021.46036
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2970
dc.identifier.volume32en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTR- Dizinen_US
dc.relation.ispartofSouthern Clinics of Istanbul Eurasiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeuroinflammationen_US
dc.subjectResolvin D1en_US
dc.subjectSubarachnoid Haemorrhageen_US
dc.subjectVasospasmen_US
dc.titleComparison of resolvin D1 levels in patients with aneurysmal subarachnoid haemorrhage with those in healthy controlsen_US
dc.typeArticleen_US

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