A Comparative Study on In vitro Anti-cancer and In vivo Anti-angiogenic Effects of TRPC Blockers Pyr-3 and SKF-96365

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dc.authoridArmutak, Elif/0000-0002-7359-6568
dc.authoridÖztürk, A. Alper/0000-0001-9596-0538
dc.authoridUvez, Ayca/0000-0002-3875-2465;
dc.authorwosidArmutak, Elif/D-2901-2019
dc.authorwosidÖztürk, A. Alper/K-2575-2019
dc.authorwosidUvez, Ayca/AAH-8851-2019
dc.authorwosidESENER, Osman Behzat Burak/D-1598-2019
dc.contributor.authorKiyan, Hulya Tuba
dc.contributor.authorUvez, Ayca
dc.contributor.authorErkisa, Merve
dc.contributor.authorIkitimur-Armutak, Elif Ilkay
dc.contributor.authorYilmazer, Nadim
dc.contributor.authorEsener, Osman Behzat Burak
dc.contributor.authorKutucu, Deniz Erol
dc.date.accessioned2024-05-19T14:46:22Z
dc.date.available2024-05-19T14:46:22Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIntroduction Angiogenesis is involved in many physiological and pathological conditions including cancer. A number of TRP channels induce angiogenesis, promote cell proliferation or induce apoptosis in several types of human cancers. Therefore, TRP channels may be considered potential pharmacological targets for therapeutic options of disorders caused by insufficient angiogenesis or aberrant vascularization. Aims This study aimed to comparatively investigate in vitro anti-cancer and in vivo anti-angiogenic effects of TRPC blockers Pyr-3 and SKF-96365. Methods For anti-cancer effects, four cancer cell lines (MDA-MB-231, A549, PC-3, and HCT-116) were used. In vivo anti-angiogenic effects were investigated by employing in vivo CAM assay of fertilized hen eggs. Results Pyr-3 affected cell viability in a dose-dependent manner, all concentrations of SKF-96365 significantly reduced cell viability in all cell lines. Pyr-3 and SKF-96365 at concentrations of 2.5 & mu;g/pellet and 50 & mu;g/pellet, respectively inhibited in vivo angiogenesis significantly. Conclusion The concentration of 2.5 & mu;g/pellet caused no irritation, whereas 50 & mu;g/pellet produced some slight irritation. Apart from their anti-cancer effects, our findings indicate that Pyr-3 and SKF-96365 may be promising anti-angiogenic agents for the treatment of angiogenesis-related disorders.en_US
dc.identifier.doi10.2174/1570180820666230110155332
dc.identifier.endpage964en_US
dc.identifier.issn1570-1808
dc.identifier.issn1875-628X
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85159792279en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage957en_US
dc.identifier.urihttps://doi.org10.2174/1570180820666230110155332
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5508
dc.identifier.volume20en_US
dc.identifier.wosWOS:001018355100015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofLetters In Drug Design & Discoveryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPyr-3en_US
dc.subjectSkf-96365en_US
dc.subjectCanceren_US
dc.subjectAngiogenesisen_US
dc.subjectIn Vivo Cam Assayen_US
dc.subjectCorpus Luteum Formationen_US
dc.titleA Comparative Study on In vitro Anti-cancer and In vivo Anti-angiogenic Effects of TRPC Blockers Pyr-3 and SKF-96365en_US
dc.typeArticleen_US

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