Male Human Papillomavirus Infection and Genotyping in Turkey

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dc.contributor.authorTekkesin, N.
dc.contributor.authorGoktas, S.
dc.contributor.authorAlkis, V.
dc.contributor.authorTekkesin, E.
dc.contributor.authorGoktas, P.
dc.date.accessioned2024-05-19T14:34:00Z
dc.date.available2024-05-19T14:34:00Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: High-risk (HR) Human Papillomavirus (HPV) has been shown to play an important role in men in various locations in Turkey. This study aims to screen the male persistent infection with the high-risk human papillomavirus (HPV) genotype status in Turkey to provide a reference basis for formulating prevention strategies for the development of genitourinary tract neoplasia. Methods: The HPV QUANT-21 Quantitative RT-PCR Kit® was used to identify and quantify low-risk HPV (HPV 6, 11, 44) and high-risk (HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82) from male individuals in Turkey. Results: Of the total 1304 samples, 473 were positive for at least one HPV genotype, with an overall frequency of 36.2%. Two-hundred fifty-four patients were positive only for one or more LR HPV genotypes (54%), and 219 patients were positive for one or more HR HPV genotypes (46%). The LR HPV genotype frequency was 53.7%, while the HR HPV genotype frequency was 46.3%. Our technology had the positive advantage of being able to calculate concentrations for each genotype. Genotype 51 was second in frequency but had the highest average concentration of 5.38 log (copies/sample). Conclusion: The presence and genotype of the virus before HPV vaccination are also of increasing importance. The data obtained will serve as a guide for prevention strategies, especially vaccination. Based on our findings there is a need of new estimates of the efficacy of currently available HPV vaccines and to develop a screening program to prevent and reduce the incidence of genitourinary tract neoplasias in Turkey. Further studies are planned to measure and define the high levels of infection that may lead to the development of cervical tumors. Using this technique, it may be possible to make clinical decisions about the extent of cytological alterations. © (2023), (Asian Pacific Organization for Cancer Prevention). All Rights Reserved.en_US
dc.description.sponsorshipWe acknowledge our technical personnel at the Molecular Biology Department of Gelisim Laboratory. Also, the authors thank you for sharing the data for this study with the laboratory director. The authors have no conflicts of interest to declare. All co-authors have seen and agree with the contents of the manuscript and there is no financial interest to report. We certify that the submission is original work and is not under review at any other publication. This study was approved by the Ethics and Research Committees of Nisantasi University, School of Medicine.en_US
dc.identifier.doi10.31557/APJCP.2023.24.12.4187
dc.identifier.endpage4193en_US
dc.identifier.issn1513-7368
dc.identifier.issue12en_US
dc.identifier.pmid38156854en_US
dc.identifier.scopus2-s2.0-85181415253en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage4187en_US
dc.identifier.urihttps://doi.org/10.31557/APJCP.2023.24.12.4187
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4390
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization for Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectGenotypeen_US
dc.subjectHigh-Risk Hpven_US
dc.subjectHpv Dnaen_US
dc.subjectHpv İnfectionen_US
dc.subjectHuman Papillomavirusen_US
dc.subjectMenen_US
dc.titleMale Human Papillomavirus Infection and Genotyping in Turkeyen_US
dc.typeArticleen_US

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