A Periodic Table approach to understand the pathophysiology of heart failure with preserved ejection fraction

Basit Öğe Kaydı
dc.contributor.authorGuvenc, Tolga Sinan
dc.contributor.authorGuvenc, Rengin Cetin
dc.contributor.authorDemir, Gizem
dc.contributor.authorNikzad, Mohammad Tahir
dc.contributor.authorEkmekci, Ahmet
dc.date.accessioned2024-05-19T14:42:18Z
dc.date.available2024-05-19T14:42:18Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractHeart failure with preserved ejection fraction is a complex syndrome that is characterized by symptoms and signs of heart failure without an apparent reduction in left ventricular ejection fraction. Although the main pathophysiologic pathways related to HFpEF are grossly understood, whether all or a specific number of mechanisms are related to the genesis of HFpEF for a given patient remains elusive. Moreover, it has been recently understood that HFpEF is a diverse disease with many phenotypes that have overlapping features, suggesting that a oneway-fits-all approach to understand the pathophysiology of this complex syndrome might not be appropriate. In this manuscript, we introduce a periodic table approach that incorporates both individual pathophysiologic pathways with consequent hemodynamic alterations, in which combinations of such pathophysiologic elements may explain the pathogenetic basis of HFpEF in each phenotype. This approach may held promise for understanding the basis of HFpEF syndrome and may contribute to the personalization of treatment approaches for each individual patient, but further evidence is needed to ascertain whether HFpEF patients have diverse pathogenetic mechanisms as suggested in the periodic table approach.en_US
dc.identifier.doi10.1016/j.mehy.2024.111298
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.scopus2-s2.0-85187533867en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1016/j.mehy.2024.111298
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5225
dc.identifier.volume185en_US
dc.identifier.wosWOS:001188700400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHeart Failureen_US
dc.subjectPathophysiologyen_US
dc.subjectPeriodic Tableen_US
dc.titleA Periodic Table approach to understand the pathophysiology of heart failure with preserved ejection fractionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu