Diffuse Leptomeningeal Glioneuronal Tumors: A Case Series of Five Patients with Parenchymal Forms and an Analysis of the Diagnostic Challenges, Treatment Options and Outcomes

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dc.authoridCelik, Serkan/0000-0002-5124-6823
dc.authoridErtem, Onder/0000-0001-9229-3469
dc.authoridKanan, Duaa/0000-0003-1943-8371
dc.authoridDemir, Mustafa Kemal/0000-0002-7023-6153
dc.authoridyapicier, ozlem/0000-0001-6977-8927
dc.authoridDincer, Alp/0000-0001-9158-8353
dc.authorwosidyapicier, ozlem/S-2580-2018
dc.authorwosidDincer, Alp/D-3658-2015
dc.contributor.authorDemir, Mustafa Kemal
dc.contributor.authorYapicier, Ozlem
dc.contributor.authorKilic, Turker
dc.contributor.authorCelik, Serkan
dc.contributor.authorOeven, Bala Basak
dc.contributor.authorOzdamarlar, Umut
dc.contributor.authorKundak, Naz Ece
dc.date.accessioned2024-05-19T14:40:51Z
dc.date.available2024-05-19T14:40:51Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground Diffuse leptomeningeal glioneuronal tumors (DL-GNT) are rare glioneuronal neoplasms with oligodendroglioma-like cells. These tumors can present as a dominant intracranial mass or as a solitary spinal cord mass without leptomeningeal involvement. In this study, we aimed to determine the magnetic resonance imaging and histopathological features, treatment modalities, and clinical outcomes of the parenchymal forms of DL-GNTs. Methods This is a retrospective three-center case series study of 5 patients with a confirmed parenchymal form of DLGTs, out of which 4 patients were adults. Brain and spinal cord MR imaging were performed in all patients at either 1.5 or 3T. The patients' age ranged from 5 years to 50 years with a mean age of 27.6 years at presentation. Results Four of the tumors were located in the frontal lobe, and one in the tectum. They were usually solid-cystic enhancing tumors as the other mixed neuronal-glial tumors. All of the tumors had an extension to the superficial surface of a cerebral hemisphere. One had systemic bone metastases. The clinical signs and symptoms of the parenchymal form varied based on the location of the mass, in contrast to the leptomeningeal form associated with hydrocephalus. In one case, the tumor's initial grade was defined as intermediate. The initial histopathology of the two cases was low-grade and no up-grade occurred in the follow-up period. In two cases, although the tumors were low grade initially, they progressed to an anaplastic form in the follow-up period. Conclusion The parenchymal form of DL-GNTs is common in adults. Extension to the superficial surface of a cerebral hemisphere is a distinctive imaging feature. Systemic osseous metastasis may occur. Due to the presence of common histopathological features, including the biphasic composition of glial and neuronal cell elements and oligodendroglioma-like cells, a proposed classification approach might be more beneficial for the histopathological and imaging description, and management of the glioneuronal tumors with oligodendroglioma-like features.en_US
dc.identifier.doi10.2174/1573405619666230213152949
dc.identifier.endpage1426en_US
dc.identifier.issn1573-4056
dc.identifier.issn1875-6603
dc.identifier.issue12en_US
dc.identifier.pmid36788686en_US
dc.identifier.startpage1415en_US
dc.identifier.urihttps://doi.org10.2174/1573405619666230213152949
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5025
dc.identifier.volume19en_US
dc.identifier.wosWOS:001023049400007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Medical Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDiffuse Leptomeningeal Glioneuronal Tumoren_US
dc.subjectGlioneuronal Tumor With Oligodendroglioma-Like Cellsen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectHistopathologyen_US
dc.subjectImmunohistochemistryen_US
dc.subjectCnsen_US
dc.titleDiffuse Leptomeningeal Glioneuronal Tumors: A Case Series of Five Patients with Parenchymal Forms and an Analysis of the Diagnostic Challenges, Treatment Options and Outcomesen_US
dc.typeArticleen_US

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