Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines

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dc.authoridDidem Karakaş Zeybek / 0000-0002-3781-6834en_US
dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidDidem Karakaş Zeybek / 56422040600
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidDidem Karakaş Zeybek / L-6682-2018
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorGökmen, Zeliha
dc.contributor.authorOnan, Mehmet Erdi
dc.contributor.authorDeniz, Nahide Gülşah
dc.contributor.authorKarakaş Zeybek, Didem
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:06:39Z
dc.date.available2020-08-30T20:06:39Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Yazılım Mühendisliği Bölümüen_US
dc.description.abstract1,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this study, new N- and S,S-substituted-1,4-NQ derivatives were synthesized in excellent yields and were completely characterized by spectroscopic analysis IR, NMR (H-1 and C-13), MS and microanalysis. The cytotoxic activities of 1,4-NQ derivatives were examined against to A-549, DU145, HCT-116 and MDA-MB-231 cancer cells. Among these compounds, 2-[4-(2-furoyl)piperazine-1-yl]-3-chloro-1,4-NQ 5 and 2,3-bis(cyclobuthylsulfanyl)-1,4-NQ 17 were identified as the most potent anticancer agents with cytotoxic activity against three cell lines (breast (MDA-MB-231), prostate (DU145), colorectal (HCT-116).en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa [56964, FBA-2018-28971]en_US
dc.description.sponsorshipThis study was funded by Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa (Project number: 56964 and Project number: FBA-2018-28971).en_US
dc.identifier.citationGokmen, Z., Onan, M. E., Deniz, N. G., Karakas, D., & Ulukaya, E. (2019). Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines. SYNTHETIC COMMUNICATIONS, 49(21), 3008–3016. https://doi.org/10.1080/00397911.2019.1655057en_US
dc.identifier.doi10.1080/00397911.2019.1655057en_US
dc.identifier.endpage3016en_US
dc.identifier.issn0039-7911en_US
dc.identifier.issn1532-2432en_US
dc.identifier.issue21en_US
dc.identifier.scopus2-s2.0-85071323535en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3008en_US
dc.identifier.urihttps://doi.org/10.1080/00397911.2019.1655057
dc.identifier.urihttps://hdl.handle.net/20.500.12713/582
dc.identifier.volume49en_US
dc.identifier.wosWOS:000484035200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKarakaş Zeybek, Didemen_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofSynthetic Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,4-Naphthoquinoneen_US
dc.subject1,4-Nqen_US
dc.subjectHeterocyclic Thioetheren_US
dc.subjectCytotoxicityen_US
dc.subjectAnticancer Agenten_US
dc.titleSynthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer linesen_US
dc.typeArticleen_US

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