Gellan gum/guar gum films incorporated with honey as potential wound dressings

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dc.authoridÖzkahraman, Bengi/0000-0003-1535-4381
dc.authoridTorkay, Gülşah/0000-0002-6803-494X
dc.authoridÖzkahraman, Bengi/0000-0003-1535-4381
dc.authoridOzbas, Zehra/0000-0001-9729-4938
dc.authorwosidÖzkahraman, Bengi/JXX-9692-2024
dc.authorwosidTorkay, Gülşah/IUP-3797-2023
dc.authorwosidÖzkahraman, Bengi/AFD-5344-2022
dc.contributor.authorBal-Ozturk, Ayca
dc.contributor.authorTorkay, Gulsah
dc.contributor.authorIdil, Neslihan
dc.contributor.authorOzkahraman, Bengi
dc.contributor.authorOzbas, Zehra
dc.date.accessioned2024-05-19T14:50:23Z
dc.date.available2024-05-19T14:50:23Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIn this article, the solvent casting technique was used to prepare wound dressing films based on honey incorporated gellan gum and guar gum biopolymers, and presented the effect of the honey concentration (in the range of 0-10 g on each film). The film structures were assessed by Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. The physical properties of the films were investigated by swelling, degradation, mechanical tests, and water vapor transmission rate. The swelling capacity of the films decreased with an increase in the honey amount, and the presence of honey increased the degradation percentage of the films. The incorporation of honey significantly enhanced the tensile strength of the film, and the increase in honey concentration caused a decrease in the water vapor transmission rate values. The antioxidant activity of the films was determined by DPPH assay, and the films showed good antioxidant abilities. The biocompatibility of the films was evaluated by using an MTT assay with biofilm extract against human skin fibroblast cells, and the wound healing activity of the films was evaluated via in vitro scratch assay. The obtained outcomes showed that the synthesized non-cytotoxic and biocompatible films supported cell migration and proliferation.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [2210/A]; General Domestic Graduate Scholarship Program [1649B022101483]en_US
dc.description.sponsorshipGTorkay would like to acknowledge the financial support from the Scientific and Technological Research Council of Turkey (TUBITAK) 2210/A General Domestic Graduate Scholarship Program (App No: 1649B022101483).en_US
dc.identifier.doi10.1007/s00289-023-04763-z
dc.identifier.endpage1228en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85150945345en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1211en_US
dc.identifier.urihttps://doi.org10.1007/s00289-023-04763-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5694
dc.identifier.volume81en_US
dc.identifier.wosWOS:000956840000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPolymer Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectWound Dressingen_US
dc.subjectGellan Gumen_US
dc.subjectGuar Gumen_US
dc.subjectHoneyen_US
dc.subjectAntioxidant Activityen_US
dc.titleGellan gum/guar gum films incorporated with honey as potential wound dressingsen_US
dc.typeArticleen_US

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