Effect of Ficus carica (fig) seed oil administration on GSH levels, necrosis and cast formation in myoglobinuric acute kidney injury

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dc.authoridRauf Onur Ek / 0000-0003-3923-0156en_US
dc.authorscopusidRauf Onur Ek / 6602290166
dc.authorwosidRauf Onur Ek / AGI-0087-2022en_US
dc.contributor.authorİşler, Derya
dc.contributor.authorŞirinyıldız, Ferhat
dc.contributor.authorEk, Rauf Onur
dc.date.accessioned2022-04-11T11:35:21Z
dc.date.available2022-04-11T11:35:21Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: In this study, the effect of applying different doses of Ficus carica (fig) seed oil obtained by cold pressing method on the kidney tissue and serum GSH level, as well as the formation of necrosis and cast in the experimental myoglobinuric acute kidney injury animal model created with glycerol was investigated. Materials and Methods: 32 Wistar albino male rats weighing 460-540 g were randomly divided into four groups of 8 each. Sham Control, MAKI, MAKI+FC3, MAKI+FC6. Urea and creatinine levels of the groups were analyzed by biochemical method. Tissue necrosis level was determined by histological analysis of kidney tissue sections. Results: While urea and creatinine levels increased significantly in the MAKI group compared to all groups, they were found to be lower in the high and low dose treatment groups with no significant difference between them. Tissue and serum GSH levels in the MAKI group were significantly decreased compared to all groups. In the MAKI+FC3 and MAKI+FC6 groups, an increase was detected in the tissue without dose difference, and in the serum only with high dose. The highest score in kidney tissue cast and necrosis levels were observed in the MAKI group, while significant improvements were detected in the treatment groups. Conclusion: Ficus carica(fig) seed oil, provided improvement in morphological damage with improvement in functional damage and increase in antioxidative capacity.en_US
dc.identifier.citationIsler, D., Sirinyildiz, F., Ek, R. O. (2022). Effect of Ficus carica (fig) seed oil administration on GSH levels, necrosis and cast formation in myoglobinuric acute kidney injury. Cukurova Medical Journal, 47(1), 152-160.en_US
dc.identifier.doi10.17826/cumj.1002023en_US
dc.identifier.endpage160en_US
dc.identifier.issn2602-3032en_US
dc.identifier.issue1en_US
dc.identifier.startpage152en_US
dc.identifier.trdizinid519946en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.1002023
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2630
dc.identifier.volume47en_US
dc.identifier.wosWOS:000767959700020en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorEk, Rauf Onur
dc.language.isoenen_US
dc.publisherCUKUROVA UNIVen_US
dc.relation.ispartofCUKUROVA MEDICAL JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectFicus Carica Seed Oilen_US
dc.subjectMyoglobinuric Acute Kidney Injuryen_US
dc.subjectNecrosisen_US
dc.subjectReduced Glutathioneen_US
dc.titleEffect of Ficus carica (fig) seed oil administration on GSH levels, necrosis and cast formation in myoglobinuric acute kidney injuryen_US
dc.typeArticleen_US

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