Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomy

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dc.authoridMadendere, Serdar/0000-0001-7020-0276
dc.authoridArda, Ersan/0000-0002-5430-6561
dc.authorwosidMadendere, Serdar/GWM-9709-2022
dc.authorwosidArda, Ersan/L-7357-2016
dc.contributor.authorMadendere, Serdar
dc.contributor.authorTurkkan, Gorkem
dc.contributor.authorArda, Ersan
dc.contributor.authorCaloglu, Vuslat Yurut
dc.contributor.authorKuyumcuoglu, Ugur
dc.date.accessioned2024-05-19T14:46:20Z
dc.date.available2024-05-19T14:46:20Z
dc.date.issued2022
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the potential relationship between biochemical progression and prognostic risk factors in patients with prostate cancer (PCa) patients undergoing radical prostatectomy (RP). Materials and Methods: After inclusion/exclusion criteria were applied, 216 patients who underwent RP were included in this study. Follow-up protocol included prostate specific antigen (PSA) measurements; every 3 months for the first year, every 6 months for the second year, and an annual check after 2 years. Preoperative and postoperative PSA measurements, pathological stage, Gleason score (GS), extraprostatic extension, positive surgical margins and seminal vesicle invasion were evaluated. Uni- and multivariable analyses were used to detect the relationship between biochemical progression, biochemical progression-free survival (BPFS) and prognostic risk factors. Results: Median follow-up was 29 months. Biochemical progression was observed in 39 (18.1%) patients, in 18 (9.7%) of 185 patients with first postoperative PSA level of <0.2 ng/dL, and 21 (67.7%) of 31 patients with first postoperative PSA level of >= 0.2 ng/dL. Patients with first postoperative PSA level of >= 0.2 ng/dL had a statistically significant higher risk of biochemical progression and shorter BPFS (odds ratio: 2.41; 95% confidence interval: 1.84-3.10; p<0.001), in univariate and multivariate analyses. Patients with GS =8 or T3-4 or positive surgical margins had a statistically significant higher risk of biochemical progression (p<0.001, p=0.003, p<0.001). Conclusion: Postoperative PSA level higher than >= 0.2 ng/dL was the most important predictor of biochemical progression and BPFS after RP. GS >= 8, T3-4 stages, and positive surgical margins are also related to biochemical progression.en_US
dc.identifier.doi10.4274/jus.galenos.2021.2021.0098
dc.identifier.endpage164en_US
dc.identifier.issn2148-9580
dc.identifier.issue3en_US
dc.identifier.startpage159en_US
dc.identifier.trdizinid1129725en_US
dc.identifier.urihttps://doi.org10.4274/jus.galenos.2021.2021.0098
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1129725
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5498
dc.identifier.volume9en_US
dc.identifier.wosWOS:000932257800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Urological Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectProstate Canceren_US
dc.subjectRadical Prostatectomyen_US
dc.subjectBiochemical Progressionen_US
dc.titleEvaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomyen_US
dc.typeArticleen_US

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