Chitosan-based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Basit Öğe Kaydı
dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorBokaie, Saied
dc.contributor.authorBigham, Ashkan
dc.contributor.authorMakvandi, Pooyan
dc.contributor.authorRabiee, Navid
dc.contributor.authorThakur, Vijay Kumar
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorSharifi, Esmaeel
dc.contributor.authorVarma, Rajender S.
dc.contributor.authorAref, Amir Reza
dc.contributor.authorWojnilowicz, Marcin
dc.contributor.authorZarrabi, Ali
dc.contributor.authorKarimi-Maleh, Hassan
dc.contributor.authorVoelcker, Nicolas H.
dc.contributor.authorMostafavi, Ebrahim
dc.contributor.authorOrive, Gorka
dc.date.accessioned2022-09-22T07:40:18Z
dc.date.available2022-09-22T07:40:18Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.descriptionGorka Orive wishes to thank the Spanish Ministry of Economy, Industry, and Competitiveness (PID2019-106094RB-I00/AEI/10.13039/501100011033) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country. The authors also appreciate the support from the Basque Country Government (Grupos Consolidados, No ref: IT907-16). Ebrahim Mostafavi would like to acknowledge the support from the National Institute of Biomedical Imaging and Bioengineering (5T32EB009035). Alan Prem Kumar was supported by a grant from the Singapore Ministry of Education (MOE-T2EP30120-0016).en_US
dc.description.abstractGreen chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS-based nanoparticles (CS-NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS-NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P-glycoprotein (P-gp) to reverse drug resistance. These nanoarchitectures can provide co-delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co-loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid-, carbon-, polymeric- and metal-based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS-NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS-NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH-sensitive release of DOX can occur. Furthermore, redox- and light-responsive CS-NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS-NPs, we expect to soon see significant progress towards clinical translation.en_US
dc.description.sponsorshipFunding information: National Institute of Biomedical Imaging and Bioengineering, Grant/Award Number: 5T32EB009035; University of the Basque Country; Ministry of Economy, Grant/Award Number: PID2019-106094RB-I00/AEIen_US
dc.identifier.citationMilad Ashrafizadeh,Kiavash Hushmandi,Sepideh Mirzaei,Saied Bokaie,Ashkan Bigham,Pooyan Makvandi,Navid Rabiee,Vijay Kumar Thakur,Alan Prem Kumar,Esmaeel Sharifi,Rajender S. Varma,Amir Reza Aref,Marcin Wojnilowicz,Ali Zarrabi,Hassan Karimi-Maleh,Nicolas H. Voelcker,Ebrahim Mostafavi,Gorka Orive; Chitosan-based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy; Bioengineering & Translational Medicine(2022); DOI: 10.1002/btm2.10325en_US
dc.identifier.doi10.1002/btm2.10325en_US
dc.identifier.issn2380-6761en_US
dc.identifier.scopus2-s2.0-85137897954en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1002/btm2.10325
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3180
dc.identifier.wosWOS:000853020200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherAICHE Online Libraryen_US
dc.relation.ispartofBioengineering & Translational Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleChitosan-based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapyen_US
dc.typeReview Articleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Bioengineering Transla Med - 2022 - Ashrafizadeh - Chitosan‐based nanoscale systems for doxorubicin delivery Exploring.pdf
Boyut:
5.07 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu