Controlled Sr(ii) ion release from in situ crosslinking electroactive hydrogels with potential for the treatment of infections

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dc.contributor.authorDemirkan, Melike Firlak
dc.contributor.authorOzturk, Dilek
dc.contributor.authorCifcibasi, Zeynep Sude
dc.contributor.authorErtan, Fatma
dc.contributor.authorHardy, John George
dc.contributor.authorNurseval Oyunlu, Asli
dc.contributor.authorDarici, Hakan
dc.date.accessioned2024-05-19T14:50:38Z
dc.date.available2024-05-19T14:50:38Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe development of electrochemical stimuli-responsive drug delivery systems is of both academic and industrial interest due to the ease with which it is possible to trigger payload release, providing drug delivery in a controllable manner. Herein, the preparation of in situ forming hydrogels including electroactive polypyrrole nanoparticles (PPy-NPs) where Sr2+ ions are electrochemically loaded for electrically triggered release of Sr2+ ions is reported. The hydrogels were characterized by a variety of techniques including Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), thermogravimetric analysis (TGA), X-ray diffraction (XRD), cyclic voltammetry (CV), etc. The cytocompatibility towards human mesenchymal stem cells (MSCs) and fibroblasts were also studied. The Sr2+ ion loaded PEC-ALD/CS/PPy-NPs hydrogel showed no significant cytotoxicity towards human mesenchymal stem cells (MSCs) and fibroblasts. Sr2+ ions were electrochemically loaded and released from the electroactive hydrogels, and the application of an electrical stimulus enhanced the release of Sr2+ ions from gels by ca. 2-4 fold relative to the passive release control experiment. The antibacterial activity of Sr2+ ions against E. coli and S. aureus was demonstrated in vitro. Although these prototypical examples of Sr2+ loaded electroactive gels don't release sufficient Sr2+ ions to show antibacterial activity against E. coli and S. aureus, we believe future iterations with optimised physical properties of the gels will be capable of doing so.en_US
dc.description.sponsorshipRoyal Society [R20-4000]; Royal Society of Chemistry (Research Fund) [BB/L0137971/1]; UKRI Biotechnology and Biological Sciences Research Council (BBSRC) Networks in Industrial Biotechnology and Bioenergy (NIBB) [BB/L013762/1]; IBCarb NIBB [BB/L013819/1]; P2P NIBB [RG160449]; Royal Societyen_US
dc.description.sponsorshipThis research was supported by the Royal Society of Chemistry (Research Fund, R20-4000) awarded to MFD. JGH thanks the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) Networks in Industrial Biotechnology and Bioenergy (NIBB) for support, specifically: FoodWasteNet NIBB (BB/L0137971/1), IBCarb NIBB (BB/L013762/1), P2P NIBB (BB/L013819/1), and the Royal Society for a Research Grant (RG160449).en_US
dc.identifier.doi10.1039/d3ra07061a
dc.identifier.endpage4334en_US
dc.identifier.issn2046-2069
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85184662631en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4324en_US
dc.identifier.urihttps://doi.org10.1039/d3ra07061a
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5766
dc.identifier.volume14en_US
dc.identifier.wosWOS:001155057300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMesenchymal Stem-Cellsen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectMetallic-Ionsen_US
dc.subjectPectinen_US
dc.subjectDifferentiationen_US
dc.subjectStimulationen_US
dc.subjectPolymersen_US
dc.subjectProteinen_US
dc.titleControlled Sr(ii) ion release from in situ crosslinking electroactive hydrogels with potential for the treatment of infectionsen_US
dc.typeArticleen_US

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