Preparation and characterization of poly(lactic acid)-based contact-active antimicrobial surfaces

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dc.authoridBalci, Huseyin/0000-0002-8778-4586
dc.authoridDoganci, Erdinc/0000-0003-2490-0671
dc.authorwosidBalci, Huseyin/A-9558-2018
dc.authorwosidCetin, Metin/AAH-2552-2019
dc.authorwosidOzkoc, Guralp/F-7917-2018
dc.authorwosidDoganci, Erdinc/V-5183-2017
dc.contributor.authorAynali, Figen
dc.contributor.authorDoganci, Erdinc
dc.contributor.authorBalci, Huseyin
dc.contributor.authorCetin, Metin
dc.contributor.authorOzkoc, Guralp
dc.contributor.authorSadikoglu, Hasan
dc.date.accessioned2024-05-19T14:46:14Z
dc.date.available2024-05-19T14:46:14Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPoly(lactic acid) (PLA)-based contact-active antimicrobial surfaces were successfully fabricated via the spray coating method. For this purpose, firstly two separate antimicrobial polymers were synthesized by introducing alkyne functionalized quaternary ammonium salt into clickable copolymer containing 30 mol% and 5 mol% of quaternary ammonium salt on their backbones. Then, these synthesized polymers were applied to coat one surface of the neat PLA films (PLA/PEG, 90/10) at the rate of 5, 15, and 25 times, respectively. Afterward, the biocidal effect of these films was considered against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria by the way of contact-active method. It was observed that the films coated with polymer containing 30 mol% of quaternary ammonium salt (QAS), even at the lowest coating amount, showed a considerably active antimicrobial property against both bacteria. The thermal, mechanical, and barrier properties of coated films were also investigated. In addition, a cytotoxicity test was performed, and it was found that the PLA film was nontoxic when it was coated with polymer containing 5 mol% of quaternary ammonium salt, even at a high coating amount. For a polymer containing 30 mol% of quaternary ammonium salt on its backbone, it was necessary to coat the films at a low rate for acceptable cytotoxicity. In conclusion, due to the contact-active behavior of covalently attached antimicrobial agents, high antibacterial activity, suitable mechanical properties, and acceptable cytocompatibility, these antimicrobial surfaces can be considered as a potential candidate for bio-based materials.en_US
dc.identifier.doi10.1007/s11998-022-00758-z
dc.identifier.endpage1475en_US
dc.identifier.issn1547-0091
dc.identifier.issn1935-3804
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85158163516en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1459en_US
dc.identifier.urihttps://doi.org10.1007/s11998-022-00758-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5476
dc.identifier.volume20en_US
dc.identifier.wosWOS:000982400700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Coatings Technology and Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPoly(Lactic Acid)en_US
dc.subjectAntimicrobial Surfaceen_US
dc.subjectSpray Coatingen_US
dc.subjectContact-Activeen_US
dc.titlePreparation and characterization of poly(lactic acid)-based contact-active antimicrobial surfacesen_US
dc.typeArticleen_US

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