Does growth hormone therapy enlarge pituitary adenomas?

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dc.authoridCengiz Kara / 0000-0002-8989-560X
dc.authorscopusidCengiz Kara / 7006430279en_US
dc.authorwosidCengiz Kara / AAI-3335-2021en_US
dc.contributor.authorBitkin Çelebi, Eda
dc.contributor.authorKara, Cengiz
dc.contributor.authorKaraman, Serap
dc.contributor.authorBaşaranoglu, Murat
dc.contributor.authorYokuş, Adem
dc.contributor.authorTuncer, Oğuz
dc.date.accessioned2022-11-08T13:17:35Z
dc.date.available2022-11-08T13:17:35Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Pituitary adenomas are detected incidentally in some cases of childhood growth hormone deficiency. Growth hormones may affect tumor growth. This study analyzed the reliability of growth hormone therapy in patients with non-functioning pituitary adenomas. Methods: The study group included 16 hypopituitary patients with incidentally detected non-functioning pituitary adenoma and treated with recombinant growth hormone. Age- and sex-matched 16 healthy children with incidental pituitary adenoma detected during investigation of chronic headache were selected as the control group. The data of the two groups were retrospectively reviewed and compared regarding the change in adenoma size over time. Results: Changes in adenoma size in the patient and control groups were -0.1 (-0.8-0.3) mm and -0.1 (-0.5-0.3) mm, respectively (p=0.664). Adenoma size growth was detected in 3 patients in the patient group and 5 patients in the control group (p=0.685). Conclusion: Our data suggest that recombinant growth hormone therapy does not produce pituitary adenomas, and thus its use is safe in growth hormone deficient children with incidentally detected non-functioning pituitary adenomas.en_US
dc.identifier.citationBitkin, E. Ç., Kara, C., Karaman, S., Başaranoğlu, M., Yokuş, A., & Tuncer, O. (2022). Does growth hormone therapy enlarge pituitary adenomas? [Büyüme Hormonu Tedavisi Hipofiz Adenomlarını Büyütür mü?] Medical Journal of Bakirkoy, 18(3), 336-340. doi:10.4274/BMJ.galenos.2022.2022.5-8en_US
dc.identifier.doi10.4274/BMJ.galenos.2022.2022.5-8en_US
dc.identifier.endpage340en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85140249068en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage336en_US
dc.identifier.trdizinid1173378en_US
dc.identifier.urihttps://doi.org/10.4274/BMJ.galenos.2022.2022.5-8
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3262
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKara, Cengiz
dc.language.isoenen_US
dc.publisherGalenos Publishing Houseen_US
dc.relation.ispartofMedical Journal of Bakirkoyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGrowth Hormone Therapyen_US
dc.subjectPediatric Endocrinologyen_US
dc.subjectPituitary Adenomaen_US
dc.titleDoes growth hormone therapy enlarge pituitary adenomas?en_US
dc.typeArticleen_US

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