Determination of antibiotic resistance and pulsed-field gel electrophoresis profiles for the extended-spectrum beta-lactamase producing Escherichia coli

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dc.authoridAhmet Cenk Andaç / 0000-0002-4545-3500en_US
dc.authorscopusidAhmet Cenk Andaç / 20336962400
dc.authorwosidAhmet Cenk Andaç / AAW-5539-2020
dc.contributor.authorÖzer, Türkan Toka
dc.contributor.authorKaragöz, Alper
dc.contributor.authorYalçın, Gözde
dc.contributor.authorAndaç, Ahmet Cenk
dc.date.accessioned2020-08-30T20:07:41Z
dc.date.available2020-08-30T20:07:41Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractBackground: Production of extended-spectrum beta-lactamase (ESBL) is one of the antibiotic resistance strategies in the bacteria. Extended spectrum beta-lactamase producing Escherichia coli (E. coli) infections alarmingly increased in recent years in Turkey. Objectives: The current study aimed at determining antibiotic resistance and genotypic profiles of ESBL-positive E. coli isolates. Methods: Forty-five ESBL-positive E. coli species were isolated from a variety of units both at the Mevlana University Foundation Hospital and the Mevlana University Medical Center at Konya province in Turkey from December 2013 to December 2014. Antibiotic resistance profile was determined by the Kirby-Bauer disk diffusion method. Genotypic profile was determined by pulsed-field gel electrophoresis (PFGE) Results: The rate of ESBL production in E. coli strains was 13.1%. The isolates were highly resistant to penicillins, cephalosporins, and monobactams, while very low resistant to carbapenems. Four PFGE profiles were identified: profile A (2%), profile B (2%), profile C (67%), and profile D (29%). Profile C, the most commonly identified profile, possessed 6 subprofiles (profiles C1-C6) with more than 85% clonal similarity; Profile C2 was the commonest identified subprofile of profile C (27%). Conclusions: Extended spectrum beta-lactamase producing E. coli strains were highly resistant to beta-lactam antibiotics.en_US
dc.identifier.citationOzer, T. T., Karagoz, A., Yalcin, G., & Andac, C. A. (2018). Determination of antibiotic resistance and pulsed-field gel electrophoresis profiles for the extended-spectrum β-lactamase producing Escherichia coli. Jundishapur Journal of Microbiology, 11(3), 1-7.en_US
dc.identifier.doi10.5812/jjm.57878en_US
dc.identifier.issn2008-3645en_US
dc.identifier.issn2008-4161en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85044970827en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.5812/jjm.57878
dc.identifier.urihttps://hdl.handle.net/20.500.12713/812
dc.identifier.volume11en_US
dc.identifier.wosWOS:000428203400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAndaç, Ahmet Cenken_US
dc.language.isoenen_US
dc.publisherAhvaz Jundishapur Univ Med Scien_US
dc.relation.ispartofJundishapur Journal of Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExtended-Spectrum Beta-Lactamaseen_US
dc.subjectResistance To Antibioticsen_US
dc.subjectPulsed-Field Gel Electrophoresisen_US
dc.subjectPfgeen_US
dc.subjectTurkeyen_US
dc.subjectEscherichia Colien_US
dc.titleDetermination of antibiotic resistance and pulsed-field gel electrophoresis profiles for the extended-spectrum beta-lactamase producing Escherichia colien_US
dc.typeArticleen_US

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