Mesenchymal stem cells derived from epicardial adipose tissue reverse cardiac remodeling in a rabbit model of myocardial infarction

Basit Öğe Kaydı
dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authoridCansu Subaşı Demir / 0000-0003-4429-0989
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.authorwosidCansu Subaşı Demir / IBW-2017-2023
dc.contributor.authorÖzkaynak, Berk
dc.contributor.authorŞahin, İrfan
dc.contributor.authorÖzenç, E.
dc.contributor.authorSubaşı Demir, Cansu
dc.contributor.authorOran, Duygu Sultan
dc.contributor.authorTotoz, Tolga
dc.contributor.authorTetikkurt, Ümit Seza
dc.contributor.authorMert, Bülent
dc.contributor.authorPolat, Adil
dc.contributor.authorOkuyan, Ertu?rul
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2021-07-05T12:43:33Z
dc.date.available2021-07-05T12:43:33Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractOBJECTIVE: Myocardial infarction (MI) is one of the most important causes of death. MI-related tissue loss and cardiac remodeling may result in heart failure. Intramyocardial injection of mesenchymal stem cells derived from adipose tissues, in acute MI animal models, has shown promising regenerative capabilities. This study aimed to investigate the myocardial regenerative capacity of epicardial adipose tissue-derived mesenchymal stem cells (ADSCs) in a rabbit model of MI. MATERIALS AND METHODS: A rabbit model of MI was performed in three groups: A sham- operated group, a control group, and a treatment group. MI was induced by coronary artery ligation via thoracotomy in the first operation. Four weeks after the first operation, intramyocardial injections of phosphate-buffered saline (PBS; control group) or ADSCs (10×106 in 100 ?L; treatment group) were performed in the peri-infarct zone. Four weeks after the second operation, rabbits were sacrificed for further analysis. RESULTS: A significant increase in ejection fraction (p<0.0001) was detected in the treatment group, along with a significant increase in vascular density (p<0.001) and a significant decrease in infarct size (p<0.05) compared to the control group. CONCLUSIONS: Epicardial adipose tissue is a rich source of mesenchymal stem cells, which can differentiate into cardiomyocytes, as well as having neoangiogenic properties. Due to its potential to ameliorate chronic ischemic changes in the heart, it may be preferable in cardiac regenerative cell therapies.en_US
dc.identifier.citationB. Özkaynak, İ. Şahin, E. Özenc, C. Subaşı, D.S. Oran, T. Totoz, Ü.S. Tetikkurt, B. Mert, A. Polat, E. Okuyan & E. Karaöz (2021). European Review for Medical and Pharmacological Sciences, Mesenchymal stem cells derived from epicardial adipose tissue reverse cardiac remodeling in a rabbit model of myocardial infarction 12 (25).en_US
dc.identifier.doi10.26355/eurrev_202106_26147en_US
dc.identifier.endpage4384en_US
dc.identifier.issn1128-3602en_US
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85108875543en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4372en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202106_26147
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1879
dc.identifier.volume25en_US
dc.identifier.wosWOS:000667182600023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSubaşı Demir, Cansu
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipose-Derived Stem Cellsen_US
dc.subjectEpicardial Adipose Tissueen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectMyocardial Regenerationen_US
dc.subjectStem Cellen_US
dc.titleMesenchymal stem cells derived from epicardial adipose tissue reverse cardiac remodeling in a rabbit model of myocardial infarctionen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
93.pdf
Boyut:
9.45 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
İSÜ Hastaneleri Makale Koleksiyonu
Temel Tıp Bilimleri Bölümü Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu