Utilizing Fe2O3 in phosphate-based glasses to enhance biocompatibility and gamma-ray absorption characteristics: A step towards understanding of Na2O/Fe2O3 translocation in P2O5-CaO-Na2O glass system

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dc.authoridTekin, Huseyin Ozan/0000-0002-0997-3488
dc.authoridKnowles, Jonathan Campbell/0000-0003-3917-3446
dc.authoridALMISNED, GHADA/0000-0001-9072-4480
dc.authoridIssa, Shams/0000-0002-9166-7497
dc.authorwosidTekin, Huseyin Ozan/J-9611-2016
dc.authorwosidKnowles, Jonathan Campbell/B-9019-2008
dc.authorwosidALMISNED, GHADA/AIF-4569-2022
dc.authorwosidIssa, Shams/M-6825-2017
dc.contributor.authorNeel, Ensanya A. Abou
dc.contributor.authorSoumya, S.
dc.contributor.authorOyhanart, Sharon R.
dc.contributor.authorKnowles, Jonathan C.
dc.contributor.authorIssa, Shams A. M.
dc.contributor.authorAlmisned, Ghada
dc.contributor.authorTekin, H. O.
dc.date.accessioned2024-05-19T14:39:24Z
dc.date.available2024-05-19T14:39:24Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIn recent years, bioactive glasses have been used in several different contexts, from dental applications to FDAapproved bone augmentation treatments. We report the incorporation consequences of Fe2O3 into P2O5-CaO-Na2O glasses to enhance the biocompatibility and gamma-ray absorption characteristics for potential medical and dental application. Phosphate-based glasses with a composition of 50P2O5.30CaO.(20-x)Na2O.(x) Fe2O3 were prepared using the melt-quenching process; x varies from 0 to 5 mol% with 1 mol% incremental increase. The fundamental biological and physical properties such as cell viability, attachment, and gamma-ray absorption of these glasses were investigated. The number and spreading of human dental pulp stem cells and human fetal osteoblasts, indicated by the density of actin-stained cytoplasm, increased on glasses with more Fe2O3 content particularly for those with 4 and 5 mol%. Incorporation of Fe2O3 into the glass system provided a significant improvement in hDPSCs and hFOBs viability. The improved cell attachment and viability with increasing the Fe2O3 content could be attributed to the enhanced durability of glasses with the formation of more hydration resistant P-O-Fe bonds. The mass attenuation coefficient values of the 50P2O5.30CaO.15Na2O.5Fe2O3 glass with a 5% Fe2O3 contribution are found to be the highest over the whole investigated energy range. The half value layer values of the 50P2O5.30CaO.15Na2O.5Fe2O3 glass are the lowest and hence more favorable. It can be concluded that increasing the Fe2O3 mol% in the P2O5-CaO-Na2O glass system is a useful method for increasing the biocompatibility and gamma-ray attenuation characteristics of P2O5-CaO-Na2O bioactive glasses for medical and dental applications.en_US
dc.description.sponsorshipPrincess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia [PNURSP2023R149]en_US
dc.description.sponsorshipThe authors would like to express their deepest gratitude to Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R149), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.en_US
dc.identifier.doi10.1016/j.ceramint.2023.02.019
dc.identifier.endpage16624en_US
dc.identifier.issn0272-8842
dc.identifier.issn1873-3956
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85148359550en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage16615en_US
dc.identifier.urihttps://doi.org10.1016/j.ceramint.2023.02.019
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4773
dc.identifier.volume49en_US
dc.identifier.wosWOS:000984542600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCeramics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBioactive Glassesen_US
dc.subjectCell Viabilityen_US
dc.subjectCell Attachmenten_US
dc.subjectGamma -Rayen_US
dc.titleUtilizing Fe2O3 in phosphate-based glasses to enhance biocompatibility and gamma-ray absorption characteristics: A step towards understanding of Na2O/Fe2O3 translocation in P2O5-CaO-Na2O glass systemen_US
dc.typeArticleen_US

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