Cardiovascular changes in WAG/Rij rats with genetic absence epilepsy: effects of chronic ethosuximide treatment

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.contributor.authorŞahin, Tuğçe Demirtaş
dc.contributor.authorUtkan, Tijen
dc.contributor.authorKarson, Ayşe
dc.contributor.authorYazir, Yusufhan
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2020-10-26T07:43:25Z
dc.date.available2020-10-26T07:43:25Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The aim of this study was to investigate the effects of chronic ethosuximide (ETX) treatment on absence seizures and cardiovascular parameters in WAG/Rij rats with genetic absence epilepsy. Materials and Methods: Eight-weeks old, male Wistar and WAG/Rij rats were divided into four groups (n=20): Wistar control, Wistar ETX, WAG/Rij control and WAG/Rij ETX. ETX groups received chronic ETX treatment (oral, 300 mg/kg/day) for 3 months. At the end of the 3-month-treatment period; the total and mean duration, also number of spike wave discharges (SWDs) were evaluated using EEG recordings. Mean arterial blood pressure (MAP) and heart rate (HR) measurements were performed. Results: ETX treatment significantly decreased the duration and frequency of SWDs in WAG/Rij rats. MAP in WAG/Rij control group was markedly higher than Wistar control group. In Wistar ETX group, HR was significantly slower than Wistar control group. KCl-induced contraction response enhanced in Wistar ETX group and diminished in WAG/Rij control group compared to Wistar control group. Conclusion: Increased MAP and vascular reactivity in WAG/Rij rats. ETX treatment did not alter cardiovascular parameters in WAG/Rij rats whereas the treatment decreased the HR and vascular reactivity without affecting MAP in Wistar rats. T-type Ca++ channels may play a role in these changes.en_US
dc.identifier.citationŞAHİN, T. D., UTKAN, T., KARSON, A., YAZIR, Y., & KARAOZ, E. Cardiovascular changes in genetic absence epileptic WAG/Rij rats: Effects of chronic ethosuximide treatment. Cukurova Medical Journal, 45(3), 769-777.en_US
dc.identifier.doi10.17826/cumj.724491en_US
dc.identifier.endpage777en_US
dc.identifier.issn2602-3032en_US
dc.identifier.issue3en_US
dc.identifier.startpage769en_US
dc.identifier.trdizinid472180en_US
dc.identifier.urihttps://doi.org/ 10.17826/cumj.724491
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1150
dc.identifier.volume45en_US
dc.identifier.wosWOS:000576735900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherCUKUROVA UNIVen_US
dc.relation.ispartofCUKUROVA MEDICAL JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbsence Epilepsyen_US
dc.subjectWAG/Rijen_US
dc.subjectEthosuximideen_US
dc.subjectHeart Rateen_US
dc.subjectBlood Pressureen_US
dc.subjectVascular Reactivityen_US
dc.titleCardiovascular changes in WAG/Rij rats with genetic absence epilepsy: effects of chronic ethosuximide treatmenten_US
dc.title.alternativeGenetik absans epilepsili WAG/Rij sıçanlarda kardiyovasküler değişiklikler: Kronik etosüksimid tedavisinin etkilerien_US
dc.typeArticleen_US

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