Serum galectin-3 and TGF-beta levels in patients with sarcoidosis

Basit Öğe Kaydı
dc.authoridŞenol Kobak / 0000-0001-8270-640Xen_US
dc.authorscopusidŞenol Kobak / 12782228700
dc.authorwosidŞenol Kobak / AAO-2482-2020
dc.contributor.authorKobak, Şenol
dc.contributor.authorAkyıldız, Muhittin
dc.contributor.authorGökduman, Ayşe
dc.contributor.authorAtabay, Tennur
dc.contributor.authorVural, Hüseyin
dc.date.accessioned2020-10-20T09:34:15Z
dc.date.available2020-10-20T09:34:15Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Sarcoidosis is a chronic granulomatous disease that develops with non-caseified granuloma formation. Galectin-3 is a multifunctional protein operating in biological processes such as fibrosis, angiogenesis, and immune activation. Purpose: This study evaluates the levels of serum galectin-3 and TGF-beta in sarcoidosis patients to determine a possible correlation with clinical findings. Material and method: Forty-four biopsy-proven sarcoidosis patients followed in a single centre and 41 age and sex-matched healthy volunteers were included in the study. The levels of serum galectin-3 and TGF-beta were evaluated by ELISA method. Results: Among the 44 sarcoidosis patients, 13(29.5%) were male and 31(70.5%) were female. The average patient age was 47.4 and the average disease duration was 3.2 years. The level of serum galectin-3 was found to be the same as in the control group and had no significance statistically (p=.977). No correlation was determined between the level of serum galectin-3 and clinical and laboratory findings of sarcoidosis (p>.05). The level of serum TGF-beta was found to be higher in the sarcoidosis patients when compared to that of the control group (p=.005). While a correlation was found between serum TGF-beta and enthesitis, sacroiliitis, and arthralgia (p=.006, p=.034, p=.02), no correlation was determined on the other clinical and laboratory findings (p>.05). Conclusion: While the level of serum galectin-3 was determined to be normal in sarcoidosis patients, a high level of serum TGF-beta was found. These findings show that TGF-beta may play an important role in sarcoidosis pathogenesis and the formation of granuloma.en_US
dc.identifier.citationKobak, S., Akyildiz, M., Gokduman, A., Atabay, T., & Vural, H. (2020). Serum Galectin-3 and TGF-Beta Levels in Patients With Sarcoidosis. Reumatologia clinica, S1699-258X(20)30204-7. Advance online publication. https://doi.org/10.1016/j.reuma.2020.08.007en_US
dc.identifier.doi10.1016/j.reuma.2020.08.007en_US
dc.identifier.isbn1699-258X
dc.identifier.pmid33067139en_US
dc.identifier.scopus2-s2.0-85092490520en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.reuma.2020.08.007
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1147
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKobak, Şenol
dc.language.isoenen_US
dc.relation.ispartofReumatol Clinen_US
dc.relation.publicationcategoryRaporen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGalectin-3en_US
dc.subjectGalectina-3en_US
dc.subjectSarcoidosisen_US
dc.subjectTGF-betaen_US
dc.titleSerum galectin-3 and TGF-beta levels in patients with sarcoidosisen_US
dc.title.alternativeNiveles séricos de galectina-3 y TGF-beta en pacientes con sarcoidosisen_US
dc.typeReporten_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
kobak2016-4 (1).pdf
Boyut:
82.87 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu