Evaluation of modified pectin/alginate buccal patches with enhanced mucoadhesive properties for drug release systems: in-vitro and ex-vivo study

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridZeynep Püren Akgüner / 0000-0002-9626-1605
dc.authorscopusidZeynep, Püren Akgüner / 57205403842en_US
dc.authorscopusidAyça Bal Öztürk / 57062000100en_US
dc.authorwosidZeynep Püren Akgüner / CBX-7589-2022
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorPüren Akgüner, Zeynep
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2021-12-27T06:11:59Z
dc.date.available2021-12-27T06:11:59Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Enstitüsü, Kök Hücre ve Doku Mühendisliği Ana Bilim Dalıen_US
dc.description.abstractA recent approach for buccal mucoadhesive system is the production of thiolated polymers via thiomer. In this study, pectin was grafted with acrylic acid before the thiolation by L-cystein and it was characterized by FTIR, 1H NMR, and TGA. Following that, modified/unmodified pectin and alginate patches were successfully fabricated by a casting method, and they were characterized by FTIR and TGA. The modified pectin/alginate patches had a higher swelling ratio than that of unmodified pectin/alginate patches. Moreover, ex-vivo mucoadhesion studies of modified pectin/alginate buccal patch was 0.11 ± 0.033 N which meant that mucoadhesion on buccal mucosa was improved as compared to unmodified pectin/alginate buccal patch. The triamcinolone acetonide release capacity of the modified pectin/alginate and unmodified pectin/alginate patches in pH 6.8 was found to be 32.6 and 28.5 mg/g, respectively. The drug release kinetic data best fitted with Korsmeyer-Peppas model for both buccal patches. To cell culture studies, drug loaded, and unloaded buccal patches had no cytotoxicity against L929 cell line. According to our results modified pectin/alginate buccal patch can be used as a promising alternative for buccal mucoadhesive drug release systems.en_US
dc.identifier.citationÖzbaş, Z., Özkahraman, B., Akgüner, Z. P., & Bal-Öztürk, A. (2021). Evaluation of modified pectin/alginate buccal patches with enhanced mucoadhesive properties for drug release systems: In-vitro and ex-vivo study. Journal of Drug Delivery Science and Technology, 102991.en_US
dc.identifier.doi10.1016/j.jddst.2021.102991en_US
dc.identifier.issn1773-2247en_US
dc.identifier.scopus2-s2.0-85121144720en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2021.102991
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2341
dc.identifier.volume67en_US
dc.identifier.wosWOS:000788086900004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorPüren Akgüner, Zeynep
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherEditions de Santeen_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBuccal Patchesen_US
dc.subjectEx-Vivo Mucoadhesion Testen_US
dc.subjectThiolated Pectinen_US
dc.subjectTriamcinolone Acetonideen_US
dc.titleEvaluation of modified pectin/alginate buccal patches with enhanced mucoadhesive properties for drug release systems: in-vitro and ex-vivo studyen_US
dc.typeArticleen_US

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