Effects of atropine on blood gas parameters and pulmonary shunt fraction
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bayrakol Medical Publisher
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Atropine has been used for a long time in anesthesia management to inhibit salivary and bronchial secretions and laryngospasm before administration of an anesthetic agent. The objective of this study was to investigate the effects of atropine blood gas parameters and pulmonary shunt fraction for the first time in the literature.Material and Methods: A total of 24 patients aged 20-75 years, hospitalized in the intensive care unit under mechanical ventilation were included in the study. 0.01 mg/kg atropine was administered intravenously and arterial and venous blood gas samples were taken at 15, 45 and 90 minutes, and the shunts were calculated. pH, PO2, PCO2, H+, HCO3 and SO2 values were measured and recorded. In addition, pulmonary shunt (QS/QT) fraction was calculated at 0, 15, 45 and 90 minutes.Results: pAO2 values were statistically significantly higher at the 15th minute (109.63 +/- 7.95) compared to the 0th minute (107.00 +/- 5.99) (p=0.006) and 90th minutes (107.55 +/- 8.28) (p=0.022). CaO2 values were statistically significantly lower at the 45th minute (13.70 +/- 1.43) compared to the 0th minute (14.70 +/- 1.66) (p=0.013) and 90th minute (14.40 +/- 1.59) (p=0.008). Shunt (Qs/Qt) values were statistically significantly lower at the 45th minute (0.12 +/- 0.17) compared to the 0th minute (0.04 +/- 0.04) (p=0.040) and 90th minutes (0.07 +/- 0.10) (p=0.007).Discussion: Administration of atropine significantly increased the pulmonary shunt, regardless of the current pathology, mechanical ventilation and treatment applied. Atropine increased the shunt at the maximum level, especially at the 45th minute. In this study, the shunt emerged as the gold standard in determining the treatment modality.
Açıklama
Anahtar Kelimeler
Anesthesia, Atropine, Blood Gas, Pulmonary Shunt, Qs, Qt Fraction
Kaynak
Annals of Clinical and Analytical Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
14
Sayı
1
