Effects of atropine on blood gas parameters and pulmonary shunt fraction

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dc.authoridBayram, Erkan/0000-0002-8527-8321
dc.authorwosidBayram, Erkan/GXN-3475-2022
dc.contributor.authorBayram, Erkan
dc.contributor.authorOzenc, Ecder
dc.date.accessioned2024-05-19T14:39:00Z
dc.date.available2024-05-19T14:39:00Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAim: Atropine has been used for a long time in anesthesia management to inhibit salivary and bronchial secretions and laryngospasm before administration of an anesthetic agent. The objective of this study was to investigate the effects of atropine blood gas parameters and pulmonary shunt fraction for the first time in the literature.Material and Methods: A total of 24 patients aged 20-75 years, hospitalized in the intensive care unit under mechanical ventilation were included in the study. 0.01 mg/kg atropine was administered intravenously and arterial and venous blood gas samples were taken at 15, 45 and 90 minutes, and the shunts were calculated. pH, PO2, PCO2, H+, HCO3 and SO2 values were measured and recorded. In addition, pulmonary shunt (QS/QT) fraction was calculated at 0, 15, 45 and 90 minutes.Results: pAO2 values were statistically significantly higher at the 15th minute (109.63 +/- 7.95) compared to the 0th minute (107.00 +/- 5.99) (p=0.006) and 90th minutes (107.55 +/- 8.28) (p=0.022). CaO2 values were statistically significantly lower at the 45th minute (13.70 +/- 1.43) compared to the 0th minute (14.70 +/- 1.66) (p=0.013) and 90th minute (14.40 +/- 1.59) (p=0.008). Shunt (Qs/Qt) values were statistically significantly lower at the 45th minute (0.12 +/- 0.17) compared to the 0th minute (0.04 +/- 0.04) (p=0.040) and 90th minutes (0.07 +/- 0.10) (p=0.007).Discussion: Administration of atropine significantly increased the pulmonary shunt, regardless of the current pathology, mechanical ventilation and treatment applied. Atropine increased the shunt at the maximum level, especially at the 45th minute. In this study, the shunt emerged as the gold standard in determining the treatment modality.en_US
dc.identifier.doi10.4328/ACAM.21445
dc.identifier.endpage74en_US
dc.identifier.issn2667-663X
dc.identifier.issue1en_US
dc.identifier.startpage70en_US
dc.identifier.urihttps://doi.org10.4328/ACAM.21445
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4674
dc.identifier.volume14en_US
dc.identifier.wosWOS:000964339100015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAnesthesiaen_US
dc.subjectAtropineen_US
dc.subjectBlood Gasen_US
dc.subjectPulmonary Shunten_US
dc.subjectQsen_US
dc.subjectQt Fractionen_US
dc.titleEffects of atropine on blood gas parameters and pulmonary shunt fractionen_US
dc.typeArticleen_US

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