Plasma apelin level in acute myocardial infarction and its relation with prognosis: a prospective study

Basit Öğe Kaydı
dc.authoridTuğba Kemaloğlu Öz / 0000-0003-1168-8237
dc.authorscopusidTuğba Kemaloğlu Öz / 55804564100
dc.authorwosidTuğba Kemaloğlu Öz / HXI-6000-2023
dc.contributor.authorGüzelburç, Özge
dc.contributor.authorDemirtunç, Refik
dc.contributor.authorAltay, Servet
dc.contributor.authorKemaloğlu Öz, Tuğba
dc.contributor.authorTayyareci, Gülşah
dc.date.accessioned2021-03-03T08:44:45Z
dc.date.available2021-03-03T08:44:45Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Apelin is a novel adipocytokine with a significant role in ischemia/reperfusion injury that is synthesized and secreted in myocardial cells and coronary endothelium. There is debate on its value for the diagnosis and prognosis of myocardial infarction. We aimed to investigate plasma apelin level in patients with acute ST segment elevation (STEMI) and non-ST segment elevation (NSTEMI) myocardial infarction and its relationship with left ventricular function and prognostic parameters. Methods: Forty-one patients with STEMI, 21 patients with NSTEMI and 10 patients as control group with normal coronary angiograms were included. Plasma apelin level at presentation was investigated regarding its relationship with other diagnostic and prognostic parameters. Results: Apelin level was significantly higher in acute myocardial infarction (0.31 ± 0.56 ng/mL) compared to control group (0.08 ± 0.05 ng/mL) (p < 0.01). Likewise, it was found to be significantly higher in STEMI group (0.45 ± 0.73 ng/mL) compared to control group (0.08 ± 0.05 ng/mL) (p < 0.01). Although apelin was higher in NSTEMI group (0.13 ± 0.10 ng/mL) compared to control group (0.08 ± 0.05 ng/mL), this difference was not statistically significant (p > 0.05). No correlation was found between apelin and NT-proBNP, hsCRP, troponin, ejection fraction (EF) and Killip score (p > 0.05). A positive correlation was found between apelin and TIMI, GRACE and Gensini scores (p < 0.05). Only GRACE score was found to be correlated with apelin in MI groups. Conclusion: Apelin level was found to be high in acute myocardial infarction. With its inotropic and vasodilator effects, apelin was thought to have a protective role against severe ischemia.en_US
dc.identifier.citationGuzelburc, O., Demirtunc, R., Altay, S., Kemaloglu Oz, T., & Tayyareci, G. (2021). Plasma apelin level in acute myocardial infarction and its relation with prognosis: A prospective study. JRSM cardiovascular disease, 10, 2048004020963970. https://doi.org/10.1177/2048004020963970en_US
dc.identifier.doi10.1177/2048004020963970en_US
dc.identifier.endpage7en_US
dc.identifier.pmid33643639en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1177/2048004020963970
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1508
dc.identifier.volume10en_US
dc.identifier.wosWOS:000620762100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKemaloğlu Öz, Tuğba
dc.language.isoenen_US
dc.publisherSAGEen_US
dc.relation.ispartofJRSM Cardiovascular Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApelinen_US
dc.subjectAcute Myocardial Infarctionen_US
dc.subjectPrognosisen_US
dc.titlePlasma apelin level in acute myocardial infarction and its relation with prognosis: a prospective studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
25.pdf
Boyut:
237.39 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu