Non-coding RNAs targeting notch signaling pathway in cancer: From proliferation to cancer therapy resistance

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dc.authoridsalimimoghadam, shokooh/0000-0002-8744-8822
dc.authoridzabihi, abbas/0000-0003-4309-6172
dc.authoridNabavi, Noushin/0000-0002-5471-6229
dc.authorwosidsalimimoghadam, shokooh/AAC-7395-2021
dc.authorwosidEntezari, Maliheh/JHT-4843-2023
dc.authorwosidHashemi, Mehrdad/JHT-4661-2023
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorHasani, Sahar
dc.contributor.authorHajimazdarany, Shima
dc.contributor.authorMirmazloomi, Seyed Reza
dc.contributor.authorMakvandy, Sara
dc.contributor.authorZabihi, Abbas
dc.contributor.authorGoldoost, Yeganeh
dc.date.accessioned2024-05-19T14:39:49Z
dc.date.available2024-05-19T14:39:49Z
dc.date.issued2022
dc.departmentİstinye Üniversitesien_US
dc.description.abstractCancer is a challenging to treat disease with a high mortality rate worldwide, nevertheless advances in science has led to a decrease in the number of death cases caused by cancer. Aberrant expression of genes occurs during tumorigenesis therefore targeting the signaling pathways that regulate these genes' expression is of importance in cancer therapy. Notch is one of the signaling pathways having interactions with other vital cell signaling molecules responsible for cellular functions such as proliferation, apoptosis, invasion, metastasis, epithelial-to-mesenchymal transition (EMT), angiogenesis, and immune evasion. Furthermore, the Notch pathway is involved in response to chemo- and radiotherapy. Thus, targeting the Notch signaling pathway in cancer therapy can be beneficial for overcoming the therapeutic gaps. Non-coding RNAs (ncRNAs) are a class of RNAs that include short ncRNAs (such as micro RNAs) and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are similar to 22 nucleotides in length while lncRNAs have more than 200 nucleotides. Both miRNAs and lncRNAs control vital cellular mechanisms in cells and affect various signaling pathways and Notch is among them. The current review aims to discuss the critical role of ncRNAs in the regulation of the Notch signaling pathway by focusing on different cancer hallmarks including proliferation, apoptosis, autophagy, EMT, invasion, metastasis, and resistance to therapies.en_US
dc.identifier.doi10.1016/j.ijblomac.2022.09.203
dc.identifier.endpage1167en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid36191781en_US
dc.identifier.startpage1151en_US
dc.identifier.urihttps://doi.org10.1016/j.ijblomac.2022.09.203
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4853
dc.identifier.volume222en_US
dc.identifier.wosWOS:000868905400006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCanceren_US
dc.subjectNotchen_US
dc.subjectMirnaen_US
dc.subjectLncrnaen_US
dc.subjectCancer Therapyen_US
dc.titleNon-coding RNAs targeting notch signaling pathway in cancer: From proliferation to cancer therapy resistanceen_US
dc.typeReview Articleen_US

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