Can M-30, M-65, and IL-6 serum levels be useful markers in the diagnosis of preeclampsia and gestational diabetes?

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Tarih

2023

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Verduci Publisher

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

- OBJECTIVE: We aimed to evaluate the maternal and fetal serum M-30, M-65 and IL -6 levels in preeclampsia and gestational diabetes mellitus (GDM) in both maternal and cord blood. PATIENTS AND METHODS: Women with pre-eclampsia (n=30), GDM (n=30), and uncomplicated pregnancy (n=28) were evaluated in a cross-sec-tional study. After clamping during delivery, the serum M-30, M-65, and IL-6 levels were measured in both maternal venous blood and cord blood.RESULTS: The serum M-30, M-65, and IL-6 levels were significantly higher in preeclampsia and GDM patients' maternal blood and cord blood samples compared to the control group. In the preeclampsia group, M-65 was significantly high-er in cord blood compared with the level in mater -nal serum, but there was no significant difference between the GDM and control groups. The con-trol group's IL-6 level in cord blood was statisti-cally significantly lower than the other groups. Al-though the M-30 value in both maternal and cord blood was statistically lower in the control group than in the GDM group, there was no significant difference between the two groups when com-pared to the preeclampsia group.CONCLUSIONS: M-30 and M-65 molecules appear to have the potential to serve as bio-chemical markers in placental diseases, partic-ularly preeclampsia and gestational diabetes. Due to the insufficient sample sizes, more re-search is needed.

Açıklama

Anahtar Kelimeler

Apoptosis, Necrosis, Inflammation, Cytokeratin-18, Preeclampsia, M-30, M-65, Preeclampsia Prediction

Kaynak

European Review For Medical and Pharmacological Sciences

WoS Q Değeri

N/A

Scopus Q Değeri

Cilt

27

Sayı

12

Künye