Can M-30, M-65, and IL-6 serum levels be useful markers in the diagnosis of preeclampsia and gestational diabetes?
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verduci Publisher
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
- OBJECTIVE: We aimed to evaluate the maternal and fetal serum M-30, M-65 and IL -6 levels in preeclampsia and gestational diabetes mellitus (GDM) in both maternal and cord blood. PATIENTS AND METHODS: Women with pre-eclampsia (n=30), GDM (n=30), and uncomplicated pregnancy (n=28) were evaluated in a cross-sec-tional study. After clamping during delivery, the serum M-30, M-65, and IL-6 levels were measured in both maternal venous blood and cord blood.RESULTS: The serum M-30, M-65, and IL-6 levels were significantly higher in preeclampsia and GDM patients' maternal blood and cord blood samples compared to the control group. In the preeclampsia group, M-65 was significantly high-er in cord blood compared with the level in mater -nal serum, but there was no significant difference between the GDM and control groups. The con-trol group's IL-6 level in cord blood was statisti-cally significantly lower than the other groups. Al-though the M-30 value in both maternal and cord blood was statistically lower in the control group than in the GDM group, there was no significant difference between the two groups when com-pared to the preeclampsia group.CONCLUSIONS: M-30 and M-65 molecules appear to have the potential to serve as bio-chemical markers in placental diseases, partic-ularly preeclampsia and gestational diabetes. Due to the insufficient sample sizes, more re-search is needed.
Açıklama
Anahtar Kelimeler
Apoptosis, Necrosis, Inflammation, Cytokeratin-18, Preeclampsia, M-30, M-65, Preeclampsia Prediction
Kaynak
European Review For Medical and Pharmacological Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
27
Sayı
12
