Exploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrix

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dc.authoridBasiri, Arefeh/0000-0002-2086-5912
dc.authoridTavakoli, Mohamadreza/0000-0002-5739-1909
dc.authoridEsmaeili, Yasaman/0000-0002-3661-0260
dc.authoridatari, mehdi/0009-0007-0876-5867
dc.authorwosidBasiri, Arefeh/V-5757-2019
dc.contributor.authorEsmaeili, Yasaman
dc.contributor.authorBidram, Elham
dc.contributor.authorBigham, Ashkan
dc.contributor.authorAtari, Mehdi
dc.contributor.authorAzadani, Reyhaneh Nasr
dc.contributor.authorTavakoli, Mohamadreza
dc.contributor.authorSalehi, Saeideh
dc.date.accessioned2024-05-19T14:47:02Z
dc.date.available2024-05-19T14:47:02Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe advancement of tissue engineering for regenerating injured tissues and organs has progressed significantly in recent years. Various techniques have been used to modify the cells' microenvironments in the targeted tissue via their extracellular environment for achieving these aims. The 3D structured scaffolds alone or combined with bioactive molecules or genes and cells hold great promise for the development of functional engineered tissues. As an emerging and state-of-the-art technology in this field, integrating tissue engineering and gene therapy, known as gene-activated matrix (GAM), has gained immense attention as a promising approach for restoring damaged or dysfunctional tissues' function and structure. Nonetheless, fabricating GAMs with low cytotoxicity, high transfection efficiency, and long-term gene delivery efficiency is still challenging. Here we provide a complete overview of different tissue engineering approaches and their ongoing preclinical research trials. Moreover, the GAM strategy with a focus on gene-activated matrix development, faithful application, and future prospects as a tissue repair and regeneration replacement is assayed. The challenges and future research prospects in regenerative medicine are also presented. Eventually, we propose that GAMs offer a basic mechanistic infrastructure for tissue engineering to pave the way for clinical translation and achieve personalized regenerative medicine.en_US
dc.description.sponsorshipIsfahan University of Medical Sciences [1400283, 1401304]en_US
dc.description.sponsorshipWe are deeply grateful to Isfahan University of Medical Sciences, Deputy of Research for their support (Grant No. 1400283 and 1401304) .en_US
dc.identifier.doi10.1016/j.aej.2023.08.080
dc.identifier.endpage169en_US
dc.identifier.issn1110-0168
dc.identifier.issn2090-2670
dc.identifier.scopus2-s2.0-85171385966en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org10.1016/j.aej.2023.08.080
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5641
dc.identifier.volume81en_US
dc.identifier.wosWOS:001118897100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofAlexandria Engineering Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectTissue Engineeringen_US
dc.subjectGene Activated Matrixen_US
dc.subjectBiomaterial-Scaffolden_US
dc.subjectGene Deliveryen_US
dc.subjectRegenerative Medicineen_US
dc.titleExploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrixen_US
dc.typeArticleen_US

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