Origanum majorana L. extract effects on kidney tissue in STZ-induced DM rats

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dc.authoridKiyak Kırmacı, Hümeysa/0000-0003-2574-4762
dc.authoridAydemir, Oğuzhan/0009-0009-5722-3049
dc.authorwosidKiyak Kırmacı, Hümeysa/JZC-7010-2024
dc.authorwosidAydemir, Oğuzhan/JUF-1451-2023
dc.contributor.authorCakar, Alican
dc.contributor.authorAydemir, Oguzhan
dc.contributor.authorKiyak-kirmaci, Huemeysa
dc.contributor.authorPolat, Elif Beyzanur
dc.contributor.authorTaskin, Turgut
dc.contributor.authorKabasakal, Levent
dc.contributor.authorElcioglu, Hatice Kubra
dc.date.accessioned2024-05-19T14:40:48Z
dc.date.available2024-05-19T14:40:48Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractDiabetes mellitus is a chronic disease characterized by decreased insulin synthesis or increased blood glucose due to insulin resistance. In this study, we aimed to investigate the protective role of Origanum majorana L. on the biochemical parameters of rats induced by streptozotocin (STZ). Male Sprague-Dawley (SD) rats weighing 300-400 g were used. Rats were divided into 3 groups control, diabetes mellitus, and diabetes mellitus + Origanum majorana L. Citrate buffer was used i.p. in the control group. To induce experimental diabetes in rats, streptozotocin (60 mg/kg) was injected intraperitoneally (i.p.). After 48 hours, rats with blood glucose values higher than 200 mg/dL were considered diabetic. Diabetic rats were divided into two groups. While the first group was not treated, the second group received 200 mg/kg of Origanum majorana L. extract for 6 weeks. In this study, Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), and creatinine values were measured in serum. Malondialdehyde (MDA) and glutathione (GSH) levels were measured in kidney and liver tissues. It was found that AST, ALT, and creatinine values increased in diabetes and decreased significantly in the treatment group. MDA levels were increased and GSH values were decreased in diabetes. Origanum majorana L. treatment decreased lipid peroxidation and resulted in a significant increase in GSH levels. In conclusion, our findings show that Origanum majorana L. treatment has a protective effect against nephropathy in diabetes by preventing oxidative damage.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Committee [SAG-C-YLP-131216-0535]en_US
dc.description.sponsorshipAcknowledgements: This study was financially supported by Marmara University Scientific Research Projects Committee (Project number: SAG-C-YLP-131216-0535) .en_US
dc.identifier.doi10.29228/jrp.448
dc.identifier.endpage1644en_US
dc.identifier.issn2630-6344
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85165888357en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1638en_US
dc.identifier.urihttps://doi.org10.29228/jrp.448
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5017
dc.identifier.volume27en_US
dc.identifier.wosWOS:001037073200018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.subjectOriganum Majorana Len_US
dc.subjectOxidative Damageen_US
dc.titleOriganum majorana L. extract effects on kidney tissue in STZ-induced DM ratsen_US
dc.typeArticleen_US

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