Exploring of miR-155-5p, miR-181b-5p, and miR-454-3p expressions in circulating cell-free RNA: insights from peripheral blood of uveal malignant melanoma patients

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dc.authorscopusidDoğan Tunay / 59185493000
dc.authorwosidDoğan Tunay / KUX-7437-2024
dc.contributor.authorMasoumeh, Hassani
dc.contributor.authorTunay, Doğan
dc.contributor.authorAkdeniz Ödemiş, Demet
dc.contributor.authorSamuray, Tuncer
dc.contributor.authorHülya, Yazıcı
dc.date.accessioned2025-04-18T10:18:17Z
dc.date.available2025-04-18T10:18:17Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Programı
dc.description.abstractThe identification of novel non-invasive biomarkers is imperative for the early diagnosis and monitoring of malignant melanoma. The objective of this study is to examine the expression levels of miR-155-5p, miR-181b-5p, and miR-454-3p in circulating cell-free RNA obtained from plasma samples of the 72 uveal malignant melanoma patients and to compare these levels with those of 72 healthy controls. The analysis showed that the expression level of the miR-181b-5p has increased 9.25 fold, and expression level of miR-155-5p has increased 6.67 fold, and miR-454-3p expression level has increased 4.14 fold in the patient group compared with the levels in the healthy control group (p = 0.005). It was found that the high expression levels of the three miRNAs were statistically significant in patients compared with in the healthy control group. The statistical evaluations between miRNA expression levels and clinical data showed that miR-155-5p had significant association with radiation therapy (p = 0.040), and miR-454-3p showed a significant association with smoking and alcohol use respectively (p = 0.009, and p = 0.026). The significantly elevated expression levels of miR-181b-5p, miR-155-5p, and miR-454-3p in the circulating cell-free RNA of plasma from uveal melanoma patients, in comparison to those in the healthy control group, suggest the potential usefulness of these biomarkers for both early diagnosis and disease monitoring. However, more extensive and future studies are needed to use these molecules in early diagnosis and disease monitoring.
dc.description.sponsorshipIstanbul University
dc.identifier.citationMasoumeh, H., Tunay, D., Demet, Ö. A., Samuray, T., & Hülya, Y. (2024). Exploring of miR-155-5p, miR-181b-5p, and miR-454-3p Expressions in Circulating Cell-Free RNA: Insights from Peripheral Blood of Uveal Malignant Melanoma Patients. Biochemical Genetics, 1-19.
dc.identifier.doi10.1007/s10528-024-10849-8
dc.identifier.issn0006-2928
dc.identifier.issn1573-4927
dc.identifier.scopus2-s2.0-85196747271
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1007/s10528-024-10849-8
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7015
dc.identifier.wosWOS:001253324500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTunay, Doğan
dc.institutionauthoridDoğan Tunay / 0000-0001-5281-7360
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBiochemical genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectUveal Melanoma
dc.subjectmiR-155-5p
dc.subjectmiR-181b-5p
dc.subjectmiR-454-3p
dc.subjectCirculating Cell Free miRNA
dc.subjectPlasma
dc.titleExploring of miR-155-5p, miR-181b-5p, and miR-454-3p expressions in circulating cell-free RNA: insights from peripheral blood of uveal malignant melanoma patients
dc.typeArticle

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