Comprehensive estrogenic/anti-estrogenic, anticancer, mutagenic/anti-mutagenic, and genotoxic/anti-genotoxic activity studies on chemically characterized black poplar and eurasian aspen propolis types

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dc.authoridSinem Helvacıoğlu / 0000-0002-3144-5024en_US
dc.authorscopusidSinem Helvacıoğlu / 57191625600en_US
dc.authorwosidSinem Helvacıoğlu / GWQ-9714-2022en_US
dc.contributor.authorGüzelmeriç, Etil
dc.contributor.authorSipahi, Hande
dc.contributor.authorHelvacıoğlu, Sinem
dc.contributor.authorDüz, Gamze
dc.contributor.authorAkyıldız, İsmail Emir
dc.contributor.authorHazar, Merve
dc.contributor.authorDilsiz, Sevtap Aydın
dc.contributor.authorAydın, Ahmet
dc.contributor.authorYeşilada, Erdem
dc.contributor.authorÖzhan, Yağmur
dc.contributor.authorHamitoğlu, Muhammed
dc.contributor.authorHelvacıoğlu, Sinem
dc.contributor.authorYaman, Beril Kadıoğlu
dc.date.accessioned2023-02-03T08:18:56Z
dc.date.available2023-02-03T08:18:56Z
dc.date.issued2023en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractPropolis is mainly composed of plant resins, and its type is named according to the primary plant origin in its composition. Identification of propolis botanical origin is essential for predicting and repeating its pharmacological activity because of the variations in chemical composition. This study aimed to compare chemical composition of black poplar (Populus nigra L.) type-propolis (PR1 and PR2) and Eurasian aspen (P. tremula L.)-type propolis (PR3) by liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique and to evaluate their biological activity profiles. According to LC-MS/MS results, in addition to marked caffeic acid phenethyl ester content in PR1 and PR2, flavonoid aglycones such as pinocembrin, chrysin, pinobanksin, and galangin were found to be dominant in these samples. On the other hand, PR3 contained relatively high concentrations of phenolic acids such as ferulic acid, p-coumaric acid, and trans-cinnamic acid. The anti-estrogenic activity test showed that PR2 exerted the highest anti-estrogenic activity by inhibiting cell proliferation by 44.6%. All propolis extracts showed anticancer activity, which was justified by decreasing activity on the 3D spheroid size in a concentration-dependent manner. Besides, all extracts showed moderate or potent antimutagenic activity in Salmonella typhimurium TA98 and TA100 strains with and without metabolic activation, respectively. In addition, the Comet assay results revealed that propolis extracts have a geno-protective effect against H2O2-induced DNA damage in CHO-K1 cells at 0.625 and 1.25 ?g/mL concentrations. Overall, the result of this study may help in preparing standardized propolis extracts and developing products with defined pharmacological benefits in the food supplements industry. © 2023 Elsevier B.V.en_US
dc.identifier.citationGuzelmeric, E., Sipahi, H., Özhan, Y., Hamitoğlu, M., Helvacıoğlu, S., Düz, G., ... & Yeşilada, E. (2023). Comprehensive estrogenic/anti-estrogenic, anticancer, mutagenic/anti-mutagenic, and genotoxic/anti-genotoxic activity studies on chemically characterized black poplar and Eurasian aspen propolis types. Journal of Pharmaceutical and Biomedical Analysis, 115241.en_US
dc.identifier.doi10.1016/j.jpba.2023.115241en_US
dc.identifier.issn0731-7085en_US
dc.identifier.scopus2-s2.0-85146181825en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1016/j.jpba.2023.115241
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3877
dc.identifier.volume226en_US
dc.identifier.wosWOS:000923680900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorHelvacıoğlu, Sinem
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer Activityen_US
dc.subjectEstrogenic/anti-Estrogenic Activityen_US
dc.subjectGenotoxic/anti-Genotoxic Activityen_US
dc.subjectLC-MS/MSen_US
dc.subjectMutagenic/anti-Mutagenic Activityen_US
dc.subjectPropolisen_US
dc.titleComprehensive estrogenic/anti-estrogenic, anticancer, mutagenic/anti-mutagenic, and genotoxic/anti-genotoxic activity studies on chemically characterized black poplar and eurasian aspen propolis typesen_US
dc.typeArticleen_US

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