Phytochemical screening and biological evaluation of Salvia hydrangea Dc. ex Benth. growing in eastern Anatolia

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dc.authoridGizem Gülsoy Toplan / 0000-0002-0544-2532
dc.authorscopusidGizem Gülsoy Toplan / 57192304526en_US
dc.authorwosidGizem Gülsoy Toplan / ECA-5991-2022
dc.contributor.authorGülsoy Toplan, Gizem
dc.contributor.authorKürkçüoğlu, Mine
dc.contributor.authorGöger, Fatih
dc.contributor.authorTaşkın, Turgut
dc.contributor.authorCivaş, Ayşe
dc.contributor.authorİşcan, Gökalp
dc.contributor.authorEcevit Genç, Gülay
dc.contributor.authorMat, Afife
dc.contributor.authorBaşer, K.Hüsnü Can
dc.date.accessioned2022-04-04T05:59:34Z
dc.date.available2022-04-04T05:59:34Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractSalvia species have lately gained significant interest as a result of their suitable utilization in various industries. In the current study, S. hydrangea, one of the most consumed sages in the eastern region of Turkey, has been evaluated for phytochemical composition as well as in vitro pharmacological potential comparatively for the first time. The phytochemical composition of S.hydrangea was investigated by LC-MS/MS, GC-FID, and GC/MS. To reveal its biological activities, antioxidant, antimicrobial, and also acetylcholinesterase activities of different solvent extracts such as water, n-hexane, chloroform, and methanol were determined. According to GC/MS analysis, the primary components of the oil were identified as camphor (46.0%), 1,8-cineole (7.5%), camphene (6.8%), limonene (6.5%), a-pinene (5.6%) and b-pinene (6.1%). Additionally, in the infusion and methanol extract, rosmarinic acid and luteolin glycoside were detected as predominant phenolics by LC-MS/MS. In DPPH·, CUPRAC, and FRAP test results of the samples indicated strong to moderate antioxidant ability in all samples studied, additionally, among them, the infusion exhibited significant acetylcholine inhibition properties comparable with galanthamine. With regard to antimicrobial activity, all of the tested microorganisms had MIC values ranging from 15 to 2000 µg/mL. Based on these findings, S. hydrangea may have promising properties for a variety of industrial applications in the pharmaceutical, food, and cosmetic industries. © 2022 SAABen_US
dc.identifier.citationToplan, G. G., Kürkçüoğlu, M., Göger, F., Taşkın, T., Civaş, A., İşcan, G., . . . Başer, K. H. C. (2022). Phytochemical screening and biological evaluation of salvia hydrangea dc. ex benth. growing in eastern anatolia. South African Journal of Botany, 147, 799-807. doi:10.1016/j.sajb.2022.03.021en_US
dc.identifier.doi10.1016/j.sajb.2022.03.021en_US
dc.identifier.endpage807en_US
dc.identifier.issn0254-6299en_US
dc.identifier.scopus2-s2.0-85126594091en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage799en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2022.03.021
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2591
dc.identifier.volume147en_US
dc.identifier.wosWOS:000820906700024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGülsoy Toplan, Gizem
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidant Activityen_US
dc.subjectGC-GC/MSen_US
dc.subjectLC-MS/MSen_US
dc.subjectSalvia Hydrangeaen_US
dc.subjectVolatile Oilen_US
dc.titlePhytochemical screening and biological evaluation of Salvia hydrangea Dc. ex Benth. growing in eastern Anatoliaen_US
dc.typeArticleen_US

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