Role of serum metalloproteinases 2 and 9 to assess the severity of COVID-19 in pregnant women: a prospective cross-sectional study

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dc.authoridCetin, Ali/0000-0002-5767-7894
dc.authorwosidguleroglu, filiz yarsilikal/AAI-1363-2019
dc.authorwosidSimsek, Arife/C-7348-2019
dc.authorwosidCetin, Ali/P-8242-2014
dc.contributor.authorCan, Esra
dc.contributor.authorBakirci, Isil Turan
dc.contributor.authorBulut, Huri
dc.contributor.authorGuler, Filiz Yarsilikal
dc.contributor.authorCetin, Ali
dc.date.accessioned2024-05-19T14:40:33Z
dc.date.available2024-05-19T14:40:33Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: To investigate the relationship between blood matrix metalloproteinases -2 and -9 levels and disease severity in pregnant women with COVID-19 infection. Material and methods: A prospective cohort study was conducted at the Kanuni Sultan Suleyman Education and Research Hospital in Istanbul, Turkey. We measured serum MMPs-2 and-9 levels of the healthy pregnant controls and pregnant women with COVID-19 and sought to assess the status of these MMPs in pregnant women with COVID-19, especially in women with a severe form of COVID-19 as diagnosed by abnormal computed tomography (CT) findings in addition to severe clinical and laboratory findings. Results: Of the healthy pregnant controls and pregnant women with COVID-19, the serum MMP-2 levels were comparable, but the MMP-9 level was lower in the pregnant women with COVID-19. Although the serum MMP2 level was somewhat lower in the women with COVID-19 with abnormal CT findings. The serum MMP-9 level of pregnant women with COVID-19 with Conclusions: In the pregnant women, COVID-19 decreases the serum MMP-9 but does not change the serum MMP-2. COVID-19 with abnormal CT findings causes minimal decrease in the serum MMP-2 but decreases the serum MMP-9 with abnormal CT findings. Considering the study variables of current study, the probability of LMWH-related MMP alterations needs to be a study topic to clarify the possible contribution of LMWH to the status of serum MMPs in pregnant women with COVID-19 especially in the women with COVID-19 with abnormal CT findings.en_US
dc.identifier.doi10.5603/GP.a2022.0108
dc.identifier.endpage644en_US
dc.identifier.issn0017-0011
dc.identifier.issn2543-6767
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85171308164en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage638en_US
dc.identifier.urihttps://doi.org10.5603/GP.a2022.0108
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4980
dc.identifier.volume94en_US
dc.identifier.wosWOS:001029406400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofGinekologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCovid-19en_US
dc.subjectPregnancyen_US
dc.subjectSerum Metalloproteinase-2en_US
dc.subjectSerum Metalloproteinase-9en_US
dc.subjectComputed Tomographyen_US
dc.subjectLmwhen_US
dc.titleRole of serum metalloproteinases 2 and 9 to assess the severity of COVID-19 in pregnant women: a prospective cross-sectional studyen_US
dc.typeArticleen_US

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