Glycosylated nanoplatforms: From glycosylation strategies to implications and opportunities for cancer theranostics

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / GSA-3718-2022
dc.contributor.authorZare, Iman
dc.contributor.authorZirak Hassan Kiadeh, Shahrzad
dc.contributor.authorVarol, Ayşegül
dc.contributor.authorÖren Varol, Tuğba
dc.contributor.authorVarol, Mehmet
dc.contributor.authorSezen, Serap
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorMostafavi, Ebrahim
dc.contributor.authorZahed Nasab, Shima
dc.contributor.authorRahi, Amid
dc.contributor.authorKhosravi, Arezoo
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2025-04-18T08:59:25Z
dc.date.available2025-04-18T08:59:25Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractGlycosylated nanoplatforms have emerged as promising tools in the field of cancer theranostics, integrating both therapeutic and diagnostic functionalities. These nanoscale platforms are composed of different materials such as lipids, polymers, carbons, and metals that can be modified with glycosyl moieties to enhance their targeting capabilities towards cancer cells. This review provides an overview of different modification strategies employed to introduce glycosylation onto nanoplatforms, including chemical conjugation, enzymatic methods, and bio-orthogonal reactions. Furthermore, the potential applications of glycosylated nanoplatforms in cancer theranostics are discussed, focusing on their roles in drug delivery, imaging, and combination therapy. The ability of these nanoplatforms to selectively target cancer cells through specific interactions with overexpressed glycan receptors is highlighted, emphasizing their potential for enhancing efficacy and reducing the side effects compared to conventional therapies. In addition, the incorporation of diagnostic components onto the glycosylated nanoplatforms provided the capability of simultaneous imaging and therapy and facilitated the real-time monitoring of treatment response. Finally, challenges and future perspectives in the development and translation of glycosylated nanoplatforms for clinical applications are addressed, including scalability, biocompatibility, and regulatory considerations. Overall, this review underscores the significant progress made in the field of glycosylated nanoplatforms and their potential to revolutionize cancer theranostics. © 2024 Elsevier B.V.
dc.description.sponsorshipE.M. would like to acknowledge the support from the National Institute of Biomedical Imaging and Bioengineering ( 5T32EB009035 ).
dc.identifier.citationZare, I., Kiadeh, S. Z. H., Varol, A., Varol, T. Ö., Varol, M., Sezen, S., ... & Zarrabi, A. (2024). Glycosylated nanoplatforms: From glycosylation strategies to implications and opportunities for cancer theranostics. Journal of Controlled Release, 371, 158-178.
dc.identifier.doi10.1016/j.jconrel.2024.05.032
dc.identifier.endpage178
dc.identifier.issn01683659
dc.identifier.scopus2-s2.0-85194377986
dc.identifier.scopusqualityQ1
dc.identifier.startpage158
dc.identifier.urihttp://dx.doi.org/10.1016/j.jconrel.2024.05.032
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6657
dc.identifier.volume371
dc.identifier.wosWOS:001250735300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Controlled Release
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCancer Theranostics
dc.subjectDrug Delivery
dc.subjectGlycosylated Nanoplatforms
dc.subjectGlycosylation Strategies
dc.subjectNanomedicine
dc.titleGlycosylated nanoplatforms: From glycosylation strategies to implications and opportunities for cancer theranostics
dc.typeOther

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